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Perspectives on Enquiry & Evidence

The world's leading supplier of statistical insight to decision-makers in the lifesciences brings you debate and discussion of the newest trends in statistics and quantitative strategy.
October 24, 2022

Cyrus Mehta on the Founding of Cytel

On the occasion of Cytel’s 35th anniversary, co-founder Professor Cyrus Mehta sits down with Dr. Esha Senchaudhuri to..
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September 2, 2022

Summer Weekend Read Roundup

Last week, we featured our final Summer Weekend Read, the last in a series designed to showcase some of our most recent..
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August 25, 2022

Cytel Presents at ICPE 2022

The International Society for Pharmacoepidemiology is hosting its “ICPE 2022: Advancing Pharmacoepidemiology and..
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August 18, 2022

Highlights from JSM 2022

The American Statistical Association’s annual Joint Statistical Meeting (JSM) gathered over 6,500 attendees from 52..
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May 26, 2022

Method of Estimation with application to the COVID-19 Pandemic

When constructing estimands a key question that arises is how to handle intercurrent events and missing data. In a..
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January 27, 2022

Winners of The Promising Zone Quiz

As a part of Cytel’s 10 Year Anniversary of the Promising Zone Design, Cytel hosted a quiz on “Keeping the Promise” –..
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December 14, 2021

Is Promising Zone Design Optimal?

In traditional clinical trial design, the sample size is often determined to detect the target treatment effect with..
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November 30, 2021

The FDA “Real-Time Oncology Review” Process

The FDA “Real-Time Oncology Review (RTOR)”[1] is an “FDA project started in 2018 to facilitate earlier submission of..
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October 29, 2021

Designing Platform Trials

A platform trial, a type of Master Protocol, is an experimental infrastructure to evaluate multiple treatments and/or..
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October 7, 2021

Non-adherence and Non-persistence

‘Drugs do not work in patients who do not take them,’ said former surgeon general C. Everett Koop. Unfortunately, the..
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October 5, 2021

The Importance of Traceability

Traceability is crucial in all steps of clinical data handling, from data collection to final analysis. The importance..
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September 8, 2021

Reconciling an old debate with modern technology

A key decision in the design of clinical trials in oncology involves whether to select progression free survival (PFS)..
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June 15, 2021

The Promising Zone Ten Years Later

Ten years ago, a seminal paper published by Cytel Founder Cyrus Mehta, introduced the Promising Zone Design to..
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May 4, 2021

New Publication on Adaptive Platform Trials

As healthcare systems across the world, continue to grapple with the pressures of COVID-19, Cytel advances yet another..
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April 28, 2021

Trial Selection: From Art to Science

Recently, Cytel co-founder Professor Cyrus Mehta noted that, “Clinical trial design selection is too much like an art,..
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March 31, 2021

Wearables and Decentralization

As decentralized clinical trials become more attractive in an era of COVID-19, the role of wearables in clinical..
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March 30, 2021

The Integration Dilemma

As of today, our Industry has not defined any approach, nor does an official regulatory agency..
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March 5, 2021

Single Arm Multi-Stage Phase 2 Cancer Trials

Early stage Phase 2 clinical trials are often designed as multi-stage single arm trials, which quickly identify..
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