Last week, Cytel Director & Research Principal Louis Dron discussed new FDA guidance on the design and conduct of trials incorporating an external control group, sometimes known as a synthetic control arm. But what are synthetic control arms and what are the potential benefits to this clinical trial design?
This week’s Winter Weekend Read features our ebook “Demystifying Synthetic Control Arms,” which provides an introduction to this single-arm trial design and discusses:
- Propensity scoring methods
- Bayesian dynamic borrowing
It also includes an illustrative case study of non-small cell lung cancer and a series of questions sponsors should ask when considering a choice between placebo-controlled and single-arm trials.
To download the complimentary ebook, click below:
The Winter Weekends Reads series features complimentary publications on a variety of topics on clinical trial design and data science. Subscribe to our weekly newsletter below and never miss a post!
Read more from Perspectives on Enquiry & Evidence:
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FDA Guidance on the Design and Conduct of Externally Controlled Trials — What to Watch
Introduction to Evidence Synthesis and Bayesian dynamic borrowing
Estimator Choice in Synthetic Control Arm Analyses
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