October 30, 2023
The past two decades have seen the adoption of great innovation in clinical trial design. Statisticians have risen to...
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August 4, 2023
“There is always the risk that interim analyses might occur after the Sufficient Information Threshold has been...
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August 1, 2023
Evaluating the efficacy and safety of novel therapies in rare indications can be challenging due to the difficulty of...
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April 18, 2023
The Inflation Reduction Act (IRA), passed in August 2022, marks a significant shift in the US healthcare landscape,...
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January 25, 2023
People think in Bayesian terms all the time: we use prior information and the evidence at hand to make decisions in our...
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January 17, 2023
When it comes to rare diseases, a handful of major challenges to drug development arise. Bayesians strategies have...
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January 13, 2023
Bayesian methods, with their ability to facilitate flexibility and learning, are often associated with early-phase...
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January 12, 2023
Statistical methods have long been fundamental to drug development, and advancements in the last few decades in...
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December 27, 2022
Bayesian methods have been playing a key role in transforming clinical research, providing a variety of new...
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December 21, 2022
Perspectives on Enquiry and Evidence features two recurring interview series: Our new Industry Voices series, in which...
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December 16, 2022
Bayesian methods have been playing a key role in transforming clinical research, and Bayesian topics are frequently...
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November 29, 2022
Bayesian methods have continuously played a key role in transforming clinical research in therapeutic areas such as...
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November 18, 2022
In the following interview, Dr. Parvin Fardipour, Quantitative Strategies & Data Science, sits down with Heather...
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November 2, 2022
Pharmaceutical research in oncology is increasingly focused on the development of therapies targeted at newly...
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October 4, 2022
Integrated Nested Laplacian Approximations (or INLA) are now starting to be used by statisticians as a key tool for...
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October 3, 2022
The wider availability of electronic health data, medical registries, and even larger proprietary datasets means that...
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September 12, 2022
In clinical trials, patient enrollment is often staggered, with data collected sequentially. When designing a clinical...
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September 9, 2022
A new trend has emerged over the last decade that has changed the way many clinical trials are conducted. Unlike...
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August 18, 2022
The American Statistical Association’s annual Joint Statistical Meeting (JSM) gathered over 6,500 attendees from 52...
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August 3, 2022
A number of late-phase clinical trial sponsors remain hesitant to employ Bayesian approaches in confirmatory settings,...
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May 16, 2022
A combination of industry and policy forces have recently changed the shape of Australia’s R&D sector, making it a...
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December 23, 2021
Cytel blogs bring you debate and discussion of the newest trends in statistics and quantitative strategy. In 2021, our...
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December 8, 2021
Despite the debate in the scientific community on adaptive sample size reassessment (SSR), noteworthy developments have...
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March 5, 2021
Early stage Phase 2 clinical trials are often designed as multi-stage single arm trials, which quickly identify...
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February 26, 2021
In the world of clinical trials, the pace of innovation is accelerating, and approaches such as Bayesian methods are...
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February 18, 2021
In the last few years, there has been a growing interest in historical borrowing or augmented trials. There is an...
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February 12, 2021
In recent times, Single arm trials are being increasingly used to assess new treatment interventions. They establish...
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February 2, 2021
As the use of master protocols becomes more prevalent in drug development, Bayesian methods are extensively used to...
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January 26, 2021
Bayesian models offer a flexible way of incorporating historical controls in the analysis of trial data (whether single...
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December 21, 2020
2020 has been an unusually difficult year as the global pandemic impacted all of our lives. This year, the Cytel blog...
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December 16, 2020
As we prepare to close the door on 2020, we asked Pantelis Vlachos, Principal/Strategic Consultant for Cytel, to share...
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December 15, 2020
When designing clinical trials, biostatisticians and clinical development teams are often faced with a conundrum. Given...
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December 9, 2020
As a part of Cytel’s Advanced Design Framework, a new Framework for the statistical design of clinical trials, Cytel...
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December 3, 2020
Increasing Clinical Development Productivity Using Statistics and Cloud-Computing The need for Re-imagining Clinical...
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November 18, 2020
The current state of the clinical trials industry faces a challenge that was only hypothetical three or four years ago....
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November 16, 2020
MUCE is a Bayesian solution for cohort expansion trials where multiple dose(s) and multiple indication(s) are tested in...
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November 11, 2020
The widespread use of cloud-computing has altered the clinical trial design process. Whereas three or four years ago,...
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November 4, 2020
Cytel has recently revealed its Advanced Design Framework, a method developed by Cytel’s thought leaders that draws on...
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October 29, 2020
Cytel has recently revealed its Advanced Design Framework, a method developed by Cytel’s thought leaders that draws on...
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October 27, 2020
Cytel recently conducted a webinar on Bayesian Dose-finding Designs for Modern Drug Development, presented by Dr. Yuan...
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October 26, 2020
Pharmaceutical and biotech companies are under pressure to deliver more and deliver faster with fewer resources. The...
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October 23, 2020
Cytel’s New Horizons Webinar Series introduces you to the latest innovations in statistical trial design. This webinar...
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October 22, 2020
In this two-part blog series, we interview Bart Heeg, Vice President HEOR and Founder at Ingress Health (A Cytel...
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October 21, 2020
Cytel has recently revealed its Advanced Design Framework, a method developed by Cytel’s thought-leaders after a decade...
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October 15, 2020
For over a decade, advanced trial design techniques have promised efficient trials with accelerated timelines,...
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October 12, 2020
Cytel and Novartis are together hosting a complimentary Bayesian Virtual Symposium and an Interactive 7-part workshop....
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September 17, 2020
Keeping up with the rapid pace of clinical development means that we need to adopt the innovative or computationally...
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September 9, 2020
Cytel’s co-founder, Nitin Patel, conducted a webinar on designing clinical trials from a program-level perspective. His...
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August 31, 2020
Pantelis Vlachos, Principal, Strategic Consultant at Cytel, conducted a webinar to introduce the capabilities of East...
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August 25, 2020
It is important to take a strategic approach to clinical development in order to minimize the potential for Phase 3...
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July 27, 2020
Cytel is conducting a webinar series on complex innovative trial designs. Dr. Thomas Burnett, Senior Research Associate...
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July 23, 2020
Just as there are numerous adaptations that fall within the umbrella of adaptive designs, there are several different...
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July 22, 2020
Cytel brings to you a new blog series on technology and Bayesian decision-making by Pantelis Vlachos,...
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June 27, 2020
Expert statisticians at Cytel have spent the past three and a half months designing and deploying dozens of trials for...
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June 18, 2020
One of the revelations of the COVID-19 pandemic is that the flexibility and potential of Bayesian designs goes far...
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February 25, 2020
Over the past decade, a new trend began to emerge, changing the way that clinical trials are conducted. Whereas...
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August 31, 2018
JSM 2018, ASA’s annual gathering of over 6500 attendees attracted statisticians and data scientists to the beautiful...
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July 2, 2018
A number of the Cytel team were in Amsterdam, 3rd- 6th June 2018 for the PSI Conference. This year’s conference was...
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October 31, 2017
As part of Cytel's new Trial Innovations Webinar Series, Pat Mitchell, Statistical Science Director at AstraZeneca...
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May 30, 2017
A recent paper The case for Bayesian methods in benefit-risk assessment: Overview and future directions (1) co-authored...
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March 24, 2017
Robust go/no-go (GNG) decision-making is essential for effectively managing risk across a clinical portfolio. In early...
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March 2, 2017
We continue our case study series with this example of a Phase 3 design that uses Bayesian decision making combined...
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April 22, 2016
FDA draft guidance on “Co development of two or more unmarketed investigational drugs for use in combination” notes...
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