March 13, 2023
Many industries have long since adopted the practice of modeling and simulating experimental scenarios. And despite..
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February 3, 2023
For clinical development and research and development teams, the Pareto Frontier can perform two functions. Let’s take..
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January 27, 2023
Should your clinical trial be adaptive? Trials that include a prospectively planned modification based on an interim..
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January 4, 2023
Returning to Cytel after the winter holidays, I am excited to begin a year that will likely prove memorable for both..
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December 27, 2022
Bayesian methods have been playing a key role in transforming clinical research, providing a variety of new..
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December 21, 2022
Perspectives on Enquiry and Evidence features two recurring interview series: Our new Industry Voices series, in which..
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December 19, 2022
Adaptive trial designs – that is, trials that include a prospectively planned modification based on an interim analysis..
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December 16, 2022
Bayesian methods have been playing a key role in transforming clinical research, and Bayesian topics are frequently..
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December 2, 2022
For 35 years, Cytel’s scientific rigor and operational excellence have enabled biotech and pharmaceutical companies to..
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November 29, 2022
Bayesian methods have continuously played a key role in transforming clinical research in therapeutic areas such as..
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October 24, 2022
On the occasion of Cytel’s 35th anniversary, co-founder Professor Cyrus Mehta sits down with Dr. Esha Senchaudhuri to..
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October 18, 2022
On the occasion of Cytel’s 35th anniversary, co-founder Professor Nitin Patel sits down with Dr. Esha Senchaudhuri to..
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October 11, 2022
On the occasion of Cytel’s 35th anniversary, our CEO Joshua Schultz sits down with Dr. Esha Senchaudhuri to discuss the..
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October 4, 2022
Integrated Nested Laplacian Approximations (or INLA) are now starting to be used by statisticians as a key tool for..
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September 23, 2022
Adaptive trial designs – that is, trials that include a prospectively planned modification based on an interim analysis..
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September 12, 2022
In clinical trials, patient enrollment is often staggered, with data collected sequentially. When designing a clinical..
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October 22, 2021
Currently, there are many treatment options for Cancer such as, Immunotherapy, Radiation Therapy, Chemotherapy etc. If..
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October 6, 2021
Master Protocols are advanced and innovative clinical trial designs that can evaluate multiple therapies and disease..
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October 1, 2021
The COVID-19 pandemic elevated the challenge of designing and executing clinical trials within a substantially..
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September 29, 2021
While there is a plethora of rare diseases, some 7000 diseases and counting, one needs to consider the statutory..
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September 24, 2021
We may be familiar with adaptive designs, but their complexity has made them difficult to implement and their benefits..
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June 30, 2021
When Cyrus Mehta introduced the Promising Zone Design over a decade ago, the new statistical method not only..
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June 23, 2021
Much of the discussion about clinical trial design considers methods to optimize performance characteristics and..
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June 18, 2021
Next week’s PSI Conference will feature Dr. Yannis Jemiai speaking on the use of Scoring Functions in the re-imagined..
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June 15, 2021
Ten years ago, a seminal paper published by Cytel Founder Cyrus Mehta, introduced the Promising Zone Design to..
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June 9, 2021
When selecting clinical trial designs, how many design options should a sponsor explore? Would a sponsor feel more..
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June 2, 2021
For many decades the Pareto Frontier has been employed by actors in the private sector to evaluate and understand the..
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May 14, 2021
When developing clinical strategy, applying familiar business principles to the specific requirements of clinical..
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April 28, 2021
Recently, Cytel co-founder Professor Cyrus Mehta noted that, “Clinical trial design selection is too much like an art,..
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April 23, 2021
The urgent need to discover and assess the efficacy and safety of COVID-19 vaccine candidates will affect the future..
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January 26, 2021
Bayesian models offer a flexible way of incorporating historical controls in the analysis of trial data (whether single..
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December 17, 2020
As Chief Scientific Officer, Dr. Yannis Jemiai plays a pivotal role in maintaining Cytel’s well-established reputation..
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December 16, 2020
As we prepare to close the door on 2020, we asked Pantelis Vlachos, Principal/Strategic Consultant for Cytel, to share..
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December 15, 2020
When designing clinical trials, biostatisticians and clinical development teams are often faced with a conundrum. Given..
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December 9, 2020
As a part of Cytel’s Advanced Design Framework, a new Framework for the statistical design of clinical trials, Cytel..
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December 3, 2020
Increasing Clinical Development Productivity Using Statistics and Cloud-Computing The need for Re-imagining Clinical..
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November 18, 2020
The current state of the clinical trials industry faces a challenge that was only hypothetical three or four years ago...
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November 17, 2020
As a part of Cytel’s "New Horizons Webinar Series", Alind Gupta, Senior Data Scientist, presents case studies from..
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November 16, 2020
MUCE is a Bayesian solution for cohort expansion trials where multiple dose(s) and multiple indication(s) are tested in..
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November 11, 2020
The widespread use of cloud-computing has altered the clinical trial design process. Whereas three or four years ago,..
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November 4, 2020
Cytel has recently revealed its Advanced Design Framework, a method developed by Cytel’s thought leaders that draws on..
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October 29, 2020
Cytel has recently revealed its Advanced Design Framework, a method developed by Cytel’s thought leaders that draws on..
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October 21, 2020
Cytel has recently revealed its Advanced Design Framework, a method developed by Cytel’s thought-leaders after a decade..
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October 15, 2020
For over a decade, advanced trial design techniques have promised efficient trials with accelerated timelines,..
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October 1, 2020
Methods involving Group Sequential Designs is one of the earliest deviations from a traditional two-arm clinical trial..
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September 29, 2020
Innovation in trial designs are offering new routes forward for organizations of any size. They are now also aligned..
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September 9, 2020
Cytel’s co-founder, Nitin Patel, conducted a webinar on designing clinical trials from a program-level perspective. His..
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August 26, 2020
As Chief Scientific Officer, Dr. Yannis Jemiai plays a pivotal role in maintaining Cytel’s well-established reputation..
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August 25, 2020
It is important to take a strategic approach to clinical development in order to minimize the potential for Phase 3..
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August 12, 2020
Cytel’s Biostatistics and Statistical Programming team provides integrated solutions, by blending the expertise of..
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July 13, 2020
Cytel is hosting a complimentary webinar series that introduces biostatisticians and other members of the development..
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July 7, 2020
Having its roots in the seminar rooms of the Dana Farber Cancer Institute, Cytel has a long record of establishing new..
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April 29, 2020
In our previous blog, we spoke with Alind Gupta, who works as a Machine Learning Researcher at Cytel in Canada. The..
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April 20, 2020
Cytel is hosting a webinar on Transparent Machine Learning in Oncology, on April 21, 2020. Our speaker, Alind Gupta,..
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March 31, 2020
Since 1953, when the discovery of the structure of DNA was made, we have seen great advancements in genomics...
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February 20, 2020
It is widely acknowledged among drug developers that one of their most important assets is the data generated during..
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January 30, 2020
The Cytel Trial Design Innovations (CTDI) Webinar Series recently hosted a webinar on designing event-based studies...
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January 16, 2020
January’s Cytel Trial Design Innovations (CTDI) Webinar Series will feature Biostatistician and pioneering Bayesian..
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January 8, 2020
In clinical development, data is the vital ‘foundation’ that supports your programs. To successfully bring a promising..
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November 5, 2019
Cytel is delighted to have Kannan Natarajan speaking at the “Complex Innovative Trial Design Symposium and East User..
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November 12, 2018
In this blog, we talk with Robert Greene, Founder and President of the HungerNDThirst Foundation, about his upcoming..
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October 23, 2018
Cytel data scientists apply advanced statistical techniques including predictive modeling of biological processes and..
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October 5, 2018
We are delighted that Stephen Senn will be joining us at the EUGM on November 14th and 15th in Darmstadt, Germany. In..
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September 27, 2018
In this blog, we talk with Heiko Götte, Senior Expert Biostatistician at Merck about his upcoming presentation at..
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September 20, 2018
At Cytel we believe that expert statistical input has the power to shape the future of clinical development: de-risking..
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August 23, 2018
Cytel has grown significantly over the last 30 years, with operations across North America, Europe, and India. All of..
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August 15, 2018
Cytel’s 7th East User Group Meeting (EUGM) will take place on November 14 & 15, 2018 at Merck in Darmstadt, Germany,..
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July 24, 2018
At Cytel our strategic consulting team works on a wide range of projects including: Identifying the best clinical trial..
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July 3, 2018
It’s shaping up to be a busy year for Cytel’s software development team with a number of upgrades and planned..
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July 2, 2018
A number of the Cytel team were in Amsterdam, 3rd- 6th June 2018 for the PSI Conference. This year’s conference was..
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May 23, 2018
Our Industry Voices series showcases our clients’ innovative work and breakthrough therapeutics in oncologic..
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May 16, 2018
Our Industry Voices series showcases our clients’ innovative work and breakthrough therapeutics in oncologic..
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May 9, 2018
As we prepare to head to ASCO in under a month's time, we are pleased to share a new ebook that showcases some key..
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February 28, 2018
There is a consensus in the industry that data on rare diseases is limited, incomplete, and difficult to find or..
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February 13, 2018
Our strategic consulting team work on projects such as: Identifying the best clinical trial design, implementing..
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October 31, 2017
As part of Cytel's new Trial Innovations Webinar Series, Pat Mitchell, Statistical Science Director at AstraZeneca..
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October 18, 2017
Cytel's new Trial Innovations Webinar Series provides a platform for the most promising new statistical approaches..
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July 26, 2017
Sadly, clinical development of anti-cancer therapeutics faces particularly high rates of failure, even in the context..
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July 11, 2017
The Adaptive Designs and Multiple Testing Procedures Workshop (ADMTP), the first joint meeting of the Adaptive Designs..
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July 6, 2017
By Esha Senchaudhuri The ethical benefits of adaptive clinical trials have been widely acclaimed: higher prospects for..
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May 22, 2017
James (Jim) Bolognese, Senior Director, Strategic Consulting, Clinical Services at Cytel Inc. was named a 2017 fellow..
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April 25, 2017
At a recent conference Adam Hamm, Director Biostatistics at Cytel, presented his thoughts on Best Practices and..
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April 11, 2017
In a January 2017 paper (1), the FDA reviewed 22 case studies where promising Phase 2 trials did not result in..
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March 29, 2017
With an increasing interest in platform designs and other innovative designs that involve multiple comparisons over..
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October 7, 2016
Adaptive designs have the potential to accelerate clinical development, and improve the probability of trial success...
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September 29, 2016
A paper "Best practices case studies for 'less well-understood' Adaptive designs", has been published by the DIA..
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July 18, 2016
In order for adaptive designs to reach their potential, it’s critical that knowledge is effectively dissemirnated..
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April 28, 2016
Adaptive Designs in Practice: Interview with NIHR Research Fellow Munya Dimairo NIHR and University of Sheffield..
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April 22, 2016
FDA draft guidance on “Co development of two or more unmarketed investigational drugs for use in combination” notes..
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March 11, 2016
There has been increasing interest in multi-arm multi-stage trials with treatment selection and sample size..
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March 3, 2016
'The aim of a discussion should not be victory but progress.' This principle, expressed by the French essayist Joseph..
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October 1, 2015
This week marks the sixth annual American Conference on Pharmacometrics, held this year in Crystal City, VA. Situated..
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September 17, 2015
Most people familiar with adaptive clinical trial designs are familiar with those statistical designs that reject the..
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June 26, 2015
Powering a trial for superiority can be financially risky. In some instances it may also prove unnecessary.
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June 11, 2015
When the FDA first began to require pharmaceuticals to perform cardiovascular outcome trials to establish the safety of..
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May 20, 2015
Seamless adaptive clinical trials have gained popularity for reducing the projected time it takes to complete the..
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April 30, 2015
Adaptive financing (not to be confused with adaptive licensing) explores how biotechs, pharmaceuticals and potential..
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April 23, 2015
Last week the Cytel Blog discussed the benefits of using the Adaptive Maximizing Design [AM Design] for dose-finding..
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April 16, 2015
When testing certain types of new drugs it is known in advance that the adverse side-effects of the medication will..
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March 20, 2015
Sometimes a new candidate drug for a pediatric study has already been tested on adults for safety and efficacy. We know..
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February 17, 2015
21st Century Cures (also called Cures2015) is a bipartisan initiative undertaken by the Committee on Energy and..
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January 29, 2015
February 2015 marks the five year anniversary of the FDA’s Guidance on Adaptive Design Clinical Trials for Drug and..
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December 18, 2014
Earlier this week, we at Cytel enjoyed a riveting in-house discussion on the uses of Bayesian decision rules for..
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November 12, 2014
Clinical utility functions provide Phase 2 trial sponsors with an intuitive metric by which to measure the quality of a..
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October 28, 2014
Phase 1 oncology trials typically use either rule-based methods or model-based methods to determine the most acceptable..
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September 4, 2014
Imagine if we were to count the number of possible reasons that investigators might have for monitoring a biomarker..
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July 29, 2014
Adaptive designs are the unsurprising hot topic of this year’s Joint Statistical Meeting, which features over one..
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July 8, 2014
The above graphic is from Cyrus Mehta's slides on 'Adaptive Population Enrichment for Oncology Trials with Time to..
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June 5, 2014
Charles Liu, PhD, Cytel Statistician and Product Manager In the US, cancer is the most common cause of death after..
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