October 2, 2023
Patients’ adherence to the medications or treatment regimens prescribed to them by their clinicians is an important...
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September 8, 2023
Single-arm trials, unlike placebo-controlled randomized control trials, forgo the use of a placebo or standard-of-care...
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August 1, 2023
Evaluating the efficacy and safety of novel therapies in rare indications can be challenging due to the difficulty of...
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July 28, 2023
Written by Fei Tang, RWE Senior Research Consultant, and Paul Arora, Assistant Professor (Status), Dalla Lana School of...
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July 14, 2023
Written by Grammati Sarri, David Smalbrugge, Andreas Freitag, and Evie Merinopoulou The vision of a single, centralized...
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May 22, 2023
By Grammati Sarri, Evie Merinopoulou, Vinusha Kalatharan, and Jason Simeone The Canadian Agency for Drugs and...
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May 10, 2023
The evidence is staggering on the unequal health burdens experienced by specific patient groups defined by ethnic,...
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May 3, 2023
With input by Alind Gupta, Louis Dron, and Jason Simeone. Randomized clinical trials (RCTs) have long been considered...
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April 25, 2023
An interview with Miguel Hernán, Harvard University Kolokotrones Professor of Biostatistics and Epidemiology On March...
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April 18, 2023
The Inflation Reduction Act (IRA), passed in August 2022, marks a significant shift in the US healthcare landscape,...
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April 14, 2023
Real-world data and evidence are increasingly being used in health care decisions and publications. However, there are...
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March 21, 2023
One of the lesser-known complications associated with Multiple Sclerosis is a higher risk of serious infections (SIs)....
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March 8, 2023
Real-world data has been increasingly used to answer questions related to the course, prognosis, and treatment of...
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March 7, 2023
Health inequalities are an enduring issue that can be exacerbated by clinical trial recruitment that does not reflect...
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February 24, 2023
Last week, Cytel Director & Research Principal Louis Dron discussed new FDA guidance on the design and conduct of...
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February 14, 2023
The U.S. FDA has recently provided specific guidance[i] on the design and conduct of trials incorporating an external...
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January 31, 2023
Asthma affects more than 235 million people worldwide, and due to lacking effective implementation of clinical...
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November 3, 2022
Cytel will be represented at over 60 presentations at ISPOR Europe 2022, with more issue panels and workshops than any...
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October 3, 2022
The wider availability of electronic health data, medical registries, and even larger proprietary datasets means that...
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September 28, 2022
The landscape of drug development has changed dramatically over the last few decades, and effective statistical leaders...
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September 27, 2022
On Louis Dron et al., “Data Capture and Sharing in the COVID-19 Pandemic: A Cause for Concern,” The Lancet 4 (10) (2022)
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September 9, 2022
A new trend has emerged over the last decade that has changed the way many clinical trials are conducted. Unlike...
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August 25, 2022
The International Society for Pharmacoepidemiology is hosting its “ICPE 2022: Advancing Pharmacoepidemiology and...
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July 27, 2022
Written by Jing Ping Yeo and Charles Warne Adaptive designs are studies that “include a prospectively planned...
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July 26, 2022
To watch this webinar and others from this introductory series, click the link below. The ability to draw on electronic...
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July 7, 2022
The gold standard for assessing the efficacy for a medicine continues to be RCTs, however, for many reasons (disease...
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May 12, 2022
Synthetic control arm (SCA) methods are statistical methods that are seeing rapidly increasing use in comparative...
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May 5, 2022
While randomized control trials remain the industry gold-standard for regulatory and reimbursement submissions, there...
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April 29, 2022
At ISPOR US 2022, Cytel’s HEOR & RWE experts will be contributing to a range of Issue Panels, In-person Podium...
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April 13, 2022
The Life Sciences landscape has seen an impactful digital evolution in the past two years. The pandemic has accelerated...
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January 20, 2022
Limited patient populations resulting in small study sample sizes is a difficulty associated with the development of...
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October 21, 2021
A number of methods currently exist to measure non-adherence and non-persistence of medical therapies, for improved...
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October 7, 2021
‘Drugs do not work in patients who do not take them,’ said former surgeon general C. Everett Koop. Unfortunately, the...
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August 20, 2021
In clinical research, decision makers need to choose among different courses of action every day. Whether it is...
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August 5, 2021
It is important to compare competing interventions to determine value of medicines, both from clinical and societal...
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July 1, 2021
Synthetic control arms (SCAs) are best suited for situations when a single arm trial is run in a patient population...
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June 24, 2021
Synthetic control arms (SCAs) leverage real world data from various sources or evaluations of historical clinical data...
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June 17, 2021
In Part 2 of this four-part blog series, we bust another myth surrounding synthetic control arms (SCAs) used in...
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June 14, 2021
ACDM’s (Association for Clinical Data Management) eDigital data management expert group (DMEG) focuses on driving...
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June 10, 2021
Over the past decade, single arm trials have emerged as an accepted way of assessing a new treatment intervention....
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June 3, 2021
Bayesian methods allow for the incorporation of prior knowledge, in terms of either expert opinion from clinicians or...
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May 20, 2021
As more payers and HTA agencies turn to real world data to compare the effectiveness of various treatment effects, two...
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April 21, 2021
Two therapies are placed in head-to-head clinical trials when they are compared against each other as opposed to a...
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April 7, 2021
Scientists at Cytel recently published a paper in the Journal of the American Medical Association (JAMA). Among the...
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March 26, 2021
Former Commissioner of the FDA, Dr. Scott Gottlieb, in several public presentations, would bemoan missed chances to...
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February 12, 2021
In recent times, Single arm trials are being increasingly used to assess new treatment interventions. They establish...
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January 22, 2021
COVID-19 has transformed the pharmaceutical industry in a manner that few could have predicted only a year ago. One of...
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November 24, 2020
Virtual ISPOR 2020, held November 16 to 19, presented new opportunities for scientific interaction amongst HEOR...
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November 17, 2020
As a part of Cytel’s "New Horizons Webinar Series", Alind Gupta, Senior Data Scientist, presents case studies from his...
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November 12, 2020
Cytel and Ingress Health (now a Cytel company) will be contributing to a range of events at Virtual ISPOR EUROPE 2020,...
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November 5, 2020
In oncology, many manufacturers go into niche indications, where there are very specific tumors, and then they opt for...
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November 3, 2020
When an expert statistician is paired with an experienced set of data managers, opportunities to capitalize on...
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October 22, 2020
In this two-part blog series, we interview Bart Heeg, Vice President HEOR and Founder at Ingress Health (A Cytel...
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October 20, 2020
In this interview with Thomas Wilke, Principal Scientist at Ingress-Health (a Cytel company), we talk to him about his...
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October 19, 2020
COVID-19 has created extreme uncertainties -- a dearth of historical information combined with the need for safety,...
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October 14, 2020
A credible evidence base is needed to support and document the economic value of new technologies and therapeutic...
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October 13, 2020
The combination of greater access to electronic health records, bigger electronic claims datasets, and the need for...
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October 7, 2020
With the rise in digital technologies, there has been an explosion in the volume and type of data sources. We can...
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September 25, 2020
Regulators in both the United States and Europe have responded positively to the use of synthetic control arms (SCA)s...
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September 22, 2020
Research Scientists, Thomas Wilke and Sabrina Mueller recently published a manuscript on “Diabetes-Related...
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September 16, 2020
Synthetic control arms (SCA) are virtual trial arms that use historical claims data and observational data to simulate...
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September 10, 2020
Single arm trials are emerging as an accepted way of assessing a new treatment intervention. They establish clinical...
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August 7, 2020
Recently a biotech approached Cytel for support with a Phase 2 Study in oncology. Regulators had requested a natural...
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August 5, 2020
Cytel is conducting two pilot projects on head-to-head comparisons using real world data. These projects in oncology...
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July 23, 2020
Just as there are numerous adaptations that fall within the umbrella of adaptive designs, there are several different...
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May 22, 2020
The Cytel Trial Tracker now features summary plots that display trials by country, trial status and study design. This...
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April 29, 2020
In our previous blog, we spoke with Alind Gupta, who works as a Machine Learning Researcher at Cytel in Canada. The...
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April 20, 2020
Cytel is hosting a webinar on Transparent Machine Learning in Oncology, on April 21, 2020. Our speaker, Alind Gupta,...
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