Perspectives on Enquiry & Evidence

Cytel's blog featuring the latest industry insights.

Reflections on the RCT DUPLICATE Study and Increasing Confidence in Real-World Evidence

Randomized clinical trials (RCTs) have long been considered the gold standard for assessing the efficacy of medical treatments, but real-world evidence (RWE) is often more representative of routine clinical care. The RCT DUPLICATE study makes great strides in comparing the two, but the study has its limitations: notably, the lack of quantitative bias analysis.

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May 22, 2023

New CADTH Guidance on RWE Is Now Available, but Critical Aspects Are Still Missing

By Grammati Sarri, Evie Merinopoulou, Vinusha Kalatharan, and Jason Simeone The Canadian Agency for Drugs and..

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May 10, 2023

FDA Increases Calls for Manufacturers to Ensure Trial Diversity, but Does It Fall Short of Addressing Health Inequalities in Product Development?

The evidence is staggering on the unequal health burdens experienced by specific patient groups defined by ethnic,..

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May 3, 2023

Reflections on the RCT DUPLICATE Study and Increasing Confidence in Real-World Evidence

With input by Alind Gupta, Louis Dron, and Jason Simeone. Randomized clinical trials (RCTs) have long been considered..

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April 25, 2023

How Target Trial Emulation Can Take the Guesswork Out of Comparative Effect Estimates in Medicare Drug Price Negotiation

An interview with Miguel Hernán, Harvard University Kolokotrones Professor of Biostatistics and Epidemiology On March..

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April 18, 2023

Navigating Comparative Effectiveness in the Inflation Reduction Act: Methodological Approaches for Healthcare Challenges

The Inflation Reduction Act (IRA), passed in August 2022, marks a significant shift in the US healthcare landscape,..

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April 14, 2023

Data Challenges (and Solutions) for Externally Controlled Trials

Real-world data and evidence are increasingly being used in health care decisions and publications. However, there are..

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March 21, 2023

Retrospective Claims Data Analysis Unlocks Discovery in Multiple Sclerosis Research

One of the lesser-known complications associated with Multiple Sclerosis is a higher risk of serious infections (SIs)...

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March 8, 2023

New Linked Database Expands Potential of RWE: A Unique Opportunity for Multiple Sclerosis Research

Real-world data has been increasingly used to answer questions related to the course, prognosis, and treatment of..

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March 7, 2023

Can RWE Help Restore Decades of Health Inequalities? Yes, and Here’s How

Grammati Sarri was recently interviewed by Inside Precision Medicine for “Improving Health Equity Starts with..

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