The Cytel Blog: Perspectives on Enquiry & Evidence

A combination of industry and policy forces have recently changed the shape of Australia’s R&D sector, making it a..

Cytel blogs bring you debate and discussion of the newest trends in statistics and quantitative strategy. In 2021, our..

Despite the debate in the scientific community on adaptive sample size reassessment (SSR), noteworthy developments have..

Early stage Phase 2 clinical trials are often designed as multi-stage single arm trials, which quickly identify..

In the world of clinical trials, the pace of innovation is accelerating, and approaches such as Bayesian methods are..

In the last few years, there has been a growing interest in historical borrowing or augmented trials. There is an..

In recent times, Single arm trials are being increasingly used to assess new treatment interventions. They establish..

As the use of master protocols becomes more prevalent in drug development, Bayesian methods are extensively used to..

Bayesian models offer a flexible way of incorporating historical controls in the analysis of trial data (whether single..