Perspectives on Enquiry & Evidence

Cytel's blog featuring the latest industry insights.

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Innovative Clinical Trial Design: Commercial vs Open-Source Software? Why Not Both?

In the ever-changing field of clinical trial design, there is often a need to evaluate design options quickly and efficiently. But when it comes to evaluating options, which is better: commercial or open-source software? And does it need to be a question of either-or?

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Perspectives on Enquiry and Evidence

December 16, 2022

Topics in Bayesian Statistical Methods

Bayesian methods have been playing a key role in transforming clinical research, and Bayesian topics are frequently...

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December 14, 2022

Accrual When Starting a Platform Trial vs. in a Stand-Alone Trial

When evaluating the efficacy of a candidate investigational therapy, a standard clinical trial paradigm is to conduct a...

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November 14, 2022

Network Meta-Interpolation: Effect Modification Adjustment in Network Meta-Analysis Using Subgroup Analyses

When conducting network meta-analysis (NMA) – that is, a technique that involves comparing multiple treatments...

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July 28, 2022

New Directions in Indirect Treatment Comparisons

When new treatments are compared with existing therapies in clinical care, population-adjustment techniques need to...

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July 27, 2022

Adaptive Designs Are Re-Defining Drug Development – Learn What's New

Written by Jing Ping Yeo and Charles Warne Adaptive designs are studies that “include a prospectively planned...

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July 26, 2022

7 Ways RWD Is Transforming Clinical Research

To watch this webinar and others from this introductory series, click the link below. The ability to draw on electronic...

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July 20, 2022

The Case for Network Meta-Interpolation to Handle Effect Modifiers in Indirect Treatment Comparisons

When performing indirect treatment comparisons, effect modification can create complexities in the event of high...

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July 13, 2022

5 Steps to Adjust for Effect Modifiers for Treatment Comparisons

Many thanks to Grammati Sarri and Michael Groff for their comments in developing this blog. An indirect treatment...

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July 12, 2022

Strategies for Selecting New Indications for a Platform Trial

Thanks to Dr. Kyle Wathen for comments on this blog. The increasing use of platform trials for the testing of a wide...

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July 7, 2022

Using Quantitative Bias Analysis in Real World Data Strategy

The gold standard for assessing the efficacy for a medicine continues to be RCTs, however, for many reasons (disease...

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June 29, 2022

Platform Trials, Master Protocols, and Challenges in Execution

How can we build an efficient statistical protocol for a clinical trial, if we do not know the therapies that will be...

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May 24, 2022

Leveraging Advanced Statistical Software to Optimize Clinical Development

Traditionally, clinical trials are expensive, long in duration, and have low success rate. But with the advent of rich...

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January 21, 2022

How to Use and Interpret the Results of a Platform Trial

For our first Winter Weekend Read, Cytel presents How to Use and Interpret the Results of a Platform Trial, a JAMA...

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November 30, 2021

Dr. Julia Edwards Findings Promising Zone Designs

The aim of any clinical research is to detect the actual difference in treatment effect between two groups (power) and...

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August 18, 2021

What does reducing the risk of a faulty conclusion mean: Case study

During the design of a clinical trial, many biotechs want to substantially reduce the risk of a good new therapy being...

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July 28, 2021

Lessons Learned from Leveraging Computing Power for Clinical Strategy

“We found an optimal design in hours that might have taken months to find using standard methods,” reflected Fabien...

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July 22, 2021

The Risk of Under-exploring Trial Design Options: A New Case Study

Earlier this year, Cytel founder Cyrus Mehta observed that clinical trial design is often treated like an art rather...

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July 14, 2021

Novel Uses of Scoring Functions in Clinical Trial Design Selection

For decades, statisticians have cultivated methods to optimize and de-risk clinical trials for strong regulatory...

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July 7, 2021

Ensuring You Get Optimal Study Power for Your Investment

Suppose a statistician were to tell a clinical trial sponsor that it was possible to improve the power of the sponsor’s...

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May 19, 2021

A Non-Technical Guide to Statistically-Informed Clinical Strategy

Clinical trial sponsors are more likely than ever to use the power of simulation and forecasting to evaluate the...

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May 12, 2021

Strategic Insights from Novel Bayesian Methods – Complimentary Paper

Did you know that Bayesian methods can strengthen Frequentist trials through the use of Bayesian decision criteria or...

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March 9, 2021

Seeing Uncertainty: New Frontiers of Statistical Communication

When statistical sciences were in their infancy, the communicative benefits of statistics were widely touted. Thousands...

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February 4, 2021

Simulation Based Clinical Trial Optimization

The past decade has witnessed the rise of simulations-based clinical trial optimization in a manner unimaginable to...

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February 1, 2021

February 2021: Updates from the CYTEL COVID-19 Trial Tracker

Cytel’s COVID-19 Trial Tracker continues to provide real time updates to the status of COVID-19 clinical trials...

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January 29, 2021

Computation and Clinical Trial Design: New Directions

Historically, advances in the statistical design of clinical trials have accompanied progress within the science and...

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January 20, 2021

Quantifying Tradeoffs in Clinical Development

One of the most difficult challenges facing Research and Development teams involves determining how to make tradeoffs...

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January 12, 2021

5 Questions to Help You Modernize Clinical Development

The rapid pace of technology has opened up numerous avenues for advanced innovative clinical trial design, but how can...

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January 11, 2021

COVID-19 Trial Tracker Updates (January 11)

In April 2020, Cytel launched an open-access global COVID-19 Clinical Trial Tracker to help facilitate greater...

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September 28, 2020

Advantages of platform designs for investigating COVID-19 therapies

Cytel has recently designed and implemented the TOGETHER Trials, funded by the Bill & Melinda Gates Foundation to...

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May 7, 2020

COVID-19: Trials, Designs and Tools for Promising Results - A Virtual Panel Discussion

An extraordinary amount of global research is underway as the COVID-19 pandemic continues to evolve and spread...

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January 30, 2020

Designing Event-based Studies: Interview with Pantelis Vlachos

The Cytel Trial Design Innovations (CTDI) Webinar Series recently hosted a webinar on designing event-based studies....

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