June 14, 2022
Suppose you had to choose six clinical trials intended for registration with regulatory agencies, only six, to explain...
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February 22, 2022
When determining the best possible statistical design for a particular trial, large pharmaceuticals and small biotechs...
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January 27, 2022
As a part of Cytel’s 10 Year Anniversary of the Promising Zone Design, Cytel hosted a quiz on “Keeping the Promise” –...
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December 23, 2021
Cytel blogs bring you debate and discussion of the newest trends in statistics and quantitative strategy. In 2021, our...
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December 20, 2021
The promising zone design is an adaptive design which allows for sample size re-estimation based on the results of an...
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December 14, 2021
In traditional clinical trial design, the sample size is often determined to detect the target treatment effect with...
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December 8, 2021
Despite the debate in the scientific community on adaptive sample size reassessment (SSR), noteworthy developments have...
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November 30, 2021
The aim of any clinical research is to detect the actual difference in treatment effect between two groups (power) and...
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November 15, 2021
Since its first publication ten years ago, Cyrus Mehta and Stuart Pocock’s Promising Zone Design for sample size...
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November 8, 2021
Ten years ago Cytel co-founder Professor Cyrus Mehta and Professor Stuart Pocock of the London School of Hygiene and...
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June 30, 2021
When Cyrus Mehta introduced the Promising Zone Design over a decade ago, the new statistical method not only...
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June 15, 2021
Ten years ago, a seminal paper published by Cytel Founder Cyrus Mehta, introduced the Promising Zone Design to...
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February 8, 2019
A 2018 publication in the Biometrical Journal by Cytel’s Cyrus Mehta, Lingyun Liu and Sam Hsiao, ‘Optimal Promising...
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August 17, 2016
Following the recent publication of their review article Adaptive Designs for Clinical Trials in the New England...
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June 26, 2015
Powering a trial for superiority can be financially risky. In some instances it may also prove unnecessary.
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March 26, 2015
Last year Sunesis completed the VALOR trial, the first clinical study to make use of the groundbreaking promising zone...
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February 10, 2015
Cardiovascular outcome trials (CVOTs) have earned the reputation of being the untamable behemoths of the clinical...
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September 18, 2014
When designing clinical trials, many trial designers are advised to keep the trial simple. Prima facie, the keep it...
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September 2, 2014
As more clinical trials make use of adaptive designs, investors have come to realize that high quality trial designs...
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May 13, 2014
The VALOR trial recently applied a promising zone design to a Phase 3 evaluation of Vosaroxin, a candidate for the...
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May 5, 2014
A new JAMA study on discontinued randomized trials in Switzerland, Germany and Canada, reports that poor recruitment...
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