Nov 21, 2016 11:42:00 AM
While adaptive designs can deliver significant benefits to clinical development- including ethical benefits for patients, reduced costs, and improved likelihood of trial success- they are not suitable for every clinical trial. In making the assessment of whether or not to choose an adaptive design, trial planners need to weigh the strategic benefits against the practical implications.
We...
Topics: adaptive trials, Clinical Development Strategy, infographic, adaptive designs, trial planning, Interim Analyses, DMC, Clinical Research Services
Jan 27, 2015 4:01:00 PM
Last week we released an infographic on why Phase 3 trials fail. The numbers, while eye-opening, did not capture a related and equally important issue: Why are so many late stage clinical trials discontinued?
Nearly 50% of all Phase 3 trials that are submitted to the FDA fail upon first submission [1]. However, 25% of all trials that begin are never even submitted for review [2]. According to a...
Topics: feasibility studies, patient enrollment, trial planning