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Keeping the Promise

Cytel Celebrates ten years of the Promising Zone Design

Ten years ago Cytel co-founder Cyrus Mehta and Professor Stuart Pocock of the London School of Hygiene and Tropical Medicine unveiled the Promising Zone, a statistical design meant to improve the power of promising study designs. Since then the Promising Zone has become an elegant tool for a variety of drug development needs from stage-gated funding to the pragmatic alignment and allocation of scarce resources. Are you a Promising Zone Afficionado? Show your Cytelligence by taking the Quiz below. Each question can have one or more answersWe will publish the names of top-scorers on the Cytel Newsroom


Email Solutions to Prizes@Cytel.com

1: When using a PZD Which of the Following Are Acceptable Decisions at the Interim look?

A: Early Stopping

B: Increase Sample Size

C: Decrease Sample Size

D: Add New Trial Arm

2: A PZD Can Be Tactically Used for Which of the Following?

A: Allocating more resources to promising studies.

B: Improving the power of a clinical trial.

C: Aligning funding with trial risk.

D: Mitigating trial risk.  

3: Which Year Did the First Trial with a PZD Unveil Its Results?

A: 2014

B: 2015

C: 2018

D: 2019

4: How many PZD designs have been approved by FDA?

A: Fewer than 10

B: More than 20 but fewer than 26

C: More than 25 but fewer than 31

D: More than 30

5: In 2021 Cyrus Mehta and co-authors Unveiled Which PZD Innovation?

A: Convex Hull Promising Zone

B: Constrained Promising Zone 

C: Jennison & Turnbull Gold-Standard for Optimality

D: Promising Zone Designs for Historical Borrowing

6: Which of the Following Are Not Features of Stage-Gated Funding?

A: Investors receive a greater expected return when a study is riskier.

B: A study in the promising zone that is successful will yield investors more than if a successful study completes on time.

C: A study that stops for efficacy will sometimes yield less to investors than a study in the promising zone.

D: A study that stops for futility will sometimes yield a greater return to investors than an unsuccessful promising zone study. 

7: Which Modules Are Necessary to Conduct Promising Zone Designs in Cytel's East?


B: East SurvADAPT



8: A PZD Cannot Be Combined with Which of the Following?

A: Seamless Adaptive Designs

B: Enrichment Designs

C: Bayesian Designs

D: Group Sequential Designs