Introduction to Population Enrichment Trial Designs
This webinar provides an overview of the SURVIVAL and SURVADAPT modules. Dealing with time-to-event endpoints, this will enable you to increase your sample size when your results look promising but lack the targeted power.
At the end of the webinar you will be able to:
- Use simulation tools to illustrate complex survival data at the design stage
- Explore trade-offs between duration and patient accrual, choice of boundaries, spending functions and hazard functions
- Utilize the promising zone to determine increases in sample size given information acquired during the trial
Meet the Speaker
Thomas Burnett, Senior Research Associate, Lancaster University
Thomas is a Senior Research Associate in Medical and Pharmaceutical Statistics at Lancaster University, where his main research interests are Adaptive clinical trials and personalised medicine. He studied for his BSc in Mathematics and Statistics with placement at the University of Bath, spending a year working on sample design at the Office for National Statistics. Thomas also holds a PhD from the University of Bath, this was a case studentship that involved working closely with Roche Products Ltd researching the Bayesian optimisation of Adaptive Enrichment trials.