Perspectives on Enquiry & Evidence

A number of late-phase clinical trial sponsors remain hesitant to employ Bayesian approaches in confirmatory settings,..

When new treatments are compared with existing therapies in clinical care, population-adjustment techniques need to..

Written by Jing Ping Yeo and Charles Warne Adaptive designs are studies that “include a prospectively planned..

Many thanks to Grammati Sarri and Michael Groff for their comments in developing this blog.   The ability to draw on..

When performing indirect treatment comparisons, effect modification can create complexities in the event of high..

Many thanks to Grammati Sarri and Michael Groff for their comments in developing this blog.   An indirect treatment..

Thanks to Dr. Kyle Wathen for comments on this blog. The increasing use of platform trials for the testing of a wide..

The gold standard for assessing the efficacy for a medicine continues to be RCTs, however, for many reasons (disease..