May 5, 2023
As clinical trials become more complex, simulation-guided design approaches are crucial. For this edition of the...
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March 24, 2023
Last week, we featured our final Winter Weekend Read, the last in a series designed to showcase our complimentary...
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March 17, 2023
Smaller clinical trials can be optimized in significant ways using simulation-guided design. A small biotech studying...
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February 22, 2023
Simulation-guided design is quickly becoming a novel feature of modern drug development. Its foundational promise is to...
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February 9, 2023
Those familiar with simulation-guided design (SGD) know that it can be used for a wealth of clinical trial options:...
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January 20, 2023
A small biotech’s conventional carcinoma trial design was too expensive to implement and did not offer the opportunity...
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January 6, 2023
You may have heard that our clinical trial strategy platform Solara® won the Fierce Life Sciences award for Technology...
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October 28, 2022
Integrating the “pressure testing” of clinical trial designs into the process of creating a strong clinical trial...
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June 2, 2022
How can clinicians at the forefront of modern clinical trials and statisticians at the forefront of advanced...
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May 24, 2022
Traditionally, clinical trials are expensive, long in duration, and have low success rate. But with the advent of rich...
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April 27, 2022
New medicines and devices under development live and die on the strength of their clinical data. An asset’s journey is...
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April 8, 2022
The planning and optimization of a clinical trial is beset by uncertainties: knowledge of treatment effects, the...
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April 5, 2022
Hello! I’m delighted to pen my inaugural blog post here as Cytel’s Chief Medical Officer. In this series, we’ll explore...
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March 23, 2022
For over a decade, the number one reason cited for trial discontinuity has been challenges associated with recruitment...
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December 23, 2021
Cytel blogs bring you debate and discussion of the newest trends in statistics and quantitative strategy. In 2021, our...
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December 7, 2021
Sponsors bringing a successful new product to market have to overcome two hurdles: submission and reimbursement. For...
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November 17, 2021
Traditionally, the teams responsible for clinical development and regulatory submissions do not consult the market...
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November 10, 2021
There are many reasons why traditional approaches to designing a clinical study are generally suboptimal and do not...
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November 2, 2021
A good clinical study design performs well not only under the ideal target scenario. Statisticians should be able to...
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October 27, 2021
A staged investment strategy aligns R&D decisions and financial planning with the interim looks of a clinical trial. If...
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October 20, 2021
For health innovators, trial selection is a key success factor as there are no second chances. But how do you find the...
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October 14, 2021
When choosing the optimal clinical trial design for a given study, sponsors face critical questions like choice of...
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September 21, 2021
Earlier this summer, we published a series of articles on the need to utilize weighting and prioritization tools in the...
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September 14, 2021
Alyssa Biller is a Senior Solutions Consultant at Cytel and currently plays a primary role in onboarding customers for...
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August 18, 2021
During the design of a clinical trial, many biotechs want to substantially reduce the risk of a good new therapy being...
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August 9, 2021
Recently we discussed examining clinical development through a Bayesian lens, in honor of Cytel co-founder Nitin Patel...
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July 28, 2021
“We found an optimal design in hours that might have taken months to find using standard methods,” reflected Fabien...
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July 22, 2021
Earlier this year, Cytel founder Cyrus Mehta observed that clinical trial design is often treated like an art rather...
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July 14, 2021
For decades, statisticians have cultivated methods to optimize and de-risk clinical trials for strong regulatory...
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July 7, 2021
Suppose a statistician were to tell a clinical trial sponsor that it was possible to improve the power of the sponsor’s...
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June 30, 2021
When Cyrus Mehta introduced the Promising Zone Design over a decade ago, the new statistical method not only...
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June 23, 2021
Much of the discussion about clinical trial design considers methods to optimize performance characteristics and...
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June 18, 2021
Next week’s PSI Conference will feature Dr. Yannis Jemiai speaking on the use of Scoring Functions in the re-imagined...
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June 14, 2021
ACDM’s (Association for Clinical Data Management) eDigital data management expert group (DMEG) focuses on driving...
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June 9, 2021
When selecting clinical trial designs, how many design options should a sponsor explore? Would a sponsor feel more...
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June 2, 2021
For many decades the Pareto Frontier has been employed by actors in the private sector to evaluate and understand the...
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May 19, 2021
Clinical trial sponsors are more likely than ever to use the power of simulation and forecasting to evaluate the...
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May 7, 2021
When is a study design considered to be optimal? A good design performs well not only under the ideal target scenario...
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March 9, 2021
When statistical sciences were in their infancy, the communicative benefits of statistics were widely touted. Thousands...
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February 4, 2021
The past decade has witnessed the rise of simulations-based clinical trial optimization in a manner unimaginable to...
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January 29, 2021
Historically, advances in the statistical design of clinical trials have accompanied progress within the science and...
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January 20, 2021
One of the most difficult challenges facing Research and Development teams involves determining how to make tradeoffs...
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January 12, 2021
The rapid pace of technology has opened up numerous avenues for advanced innovative clinical trial design, but how can...
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December 17, 2020
As Chief Scientific Officer, Dr. Yannis Jemiai plays a pivotal role in maintaining Cytel’s well-established reputation...
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