Perspectives on Enquiry & Evidence
Cytel's blog featuring the latest industry insights.
September 15, 2020
In clinical trials with small or sparse data, statistical methods meant for large sample sizes may not be helpful to...
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September 18, 2017
How to handle conservativeness of Exact p-value?
By Ashwini Joshi For small sample data or rare events data, exact non-parametric tests perform better than asymptotic...
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October 29, 2015
How to Reduce Bias in the Estimates of Count Data Regression
A common challenge of working with small sample sizes is determining proper bias correction methods when evaluating a...
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October 19, 2015
3 Statistical Challenges for Pooling Phase 1 Data
It is often necessary to pool safety data from late phase studies, in preparation for regulatory submission. Some of...
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June 25, 2015
3 Strategies to Combat Inferential Conservatism in Small Sample Sizes
When conducting a clinical trial with small or sparse data sets, statistical methods meant for large sample sizes may...
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