December 1, 2023
Last week, Robert Szulkin, Research Principal, Real World Evidence, discussed the need for real-world evidence studies,...
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September 8, 2023
Single-arm trials, unlike placebo-controlled randomized control trials, forgo the use of a placebo or standard-of-care...
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September 9, 2022
A new trend has emerged over the last decade that has changed the way many clinical trials are conducted. Unlike...
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June 8, 2022
Clinical researchers, seeking to understand the statistical benefits of a common Phase 2 oncology design, now have a...
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May 12, 2022
Synthetic control arm (SCA) methods are statistical methods that are seeing rapidly increasing use in comparative...
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May 5, 2022
While randomized control trials remain the industry gold-standard for regulatory and reimbursement submissions, there...
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April 22, 2022
This past decade has undoubtedly witnessed an increase in the number of single arm trials submitted to HTA bodies....
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November 23, 2021
A randomized clinical trial (RCT) is the gold standard approach to demonstrate the efficacy and safety of novel...
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July 1, 2021
Synthetic control arms (SCAs) are best suited for situations when a single arm trial is run in a patient population...
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June 24, 2021
Synthetic control arms (SCAs) leverage real world data from various sources or evaluations of historical clinical data...
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June 17, 2021
In Part 2 of this four-part blog series, we bust another myth surrounding synthetic control arms (SCAs) used in...
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June 10, 2021
Over the past decade, single arm trials have emerged as an accepted way of assessing a new treatment intervention....
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October 20, 2020
In this interview with Thomas Wilke, Principal Scientist at Ingress-Health (a Cytel company), we talk to him about his...
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October 14, 2020
A credible evidence base is needed to support and document the economic value of new technologies and therapeutic...
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October 13, 2020
The combination of greater access to electronic health records, bigger electronic claims datasets, and the need for...
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October 7, 2020
With the rise in digital technologies, there has been an explosion in the volume and type of data sources. We can...
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September 25, 2020
Regulators in both the United States and Europe have responded positively to the use of synthetic control arms (SCA)s...
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September 16, 2020
Synthetic control arms (SCA) are virtual trial arms that use historical claims data and observational data to simulate...
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