May 22, 2023
By Grammati Sarri, Evie Merinopoulou, Vinusha Kalatharan, and Jason Simeone The Canadian Agency for Drugs and..
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May 10, 2023
The evidence is staggering on the unequal health burdens experienced by specific patient groups defined by ethnic,..
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May 3, 2023
With input by Alind Gupta, Louis Dron, and Jason Simeone. Randomized clinical trials (RCTs) have long been considered..
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April 25, 2023
An interview with Miguel Hernán, Harvard University Kolokotrones Professor of Biostatistics and Epidemiology On March..
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April 18, 2023
The Inflation Reduction Act (IRA), passed in August 2022, marks a significant shift in the US healthcare landscape,..
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April 14, 2023
Real-world data and evidence are increasingly being used in health care decisions and publications. However, there are..
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April 5, 2023
Health technology assessment (HTA) submissions require cost effectiveness analyses based on comparative effectiveness..
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March 21, 2023
One of the lesser-known complications associated with Multiple Sclerosis is a higher risk of serious infections (SIs)...
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March 13, 2023
Many industries have long since adopted the practice of modeling and simulating experimental scenarios. And despite..
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March 8, 2023
Real-world data has been increasingly used to answer questions related to the course, prognosis, and treatment of..
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March 7, 2023
Grammati Sarri was recently interviewed by Inside Precision Medicine for “Improving Health Equity Starts with..
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March 3, 2023
The speed of scientific discovery has been outpacing the ability of researchers to accumulate and integrate constantly..
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February 14, 2023
The U.S. FDA has recently provided specific guidance[i] on the design and conduct of trials incorporating an external..
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January 31, 2023
Asthma affects more than 235 million people worldwide, and due to lacking effective implementation of clinical..
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November 3, 2022
Cytel will be represented at over 60 presentations at ISPOR Europe 2022, with more issue panels and workshops than any..
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October 13, 2022
ISPOR Europe, the leading global conference for health economics and outcomes research (HEOR) and real-world evidence..
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September 28, 2022
The landscape of drug development has changed dramatically over the last few decades, and effective statistical leaders..
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September 27, 2022
On Louis Dron et al., “Data Capture and Sharing in the COVID-19 Pandemic: A Cause for Concern,” The Lancet 4 (10) (2022)
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September 15, 2022
On August 16, 2022, President Biden signed into law the Inflation Reduction Act of 2022, which includes U.S. drug..
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August 25, 2022
The International Society for Pharmacoepidemiology is hosting its “ICPE 2022: Advancing Pharmacoepidemiology and..
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August 4, 2022
In this edition of the Career Perspectives series, I interview Allison Luccock, Director of Business Operations for..
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July 7, 2022
The gold standard for assessing the efficacy for a medicine continues to be RCTs, however, for many reasons (disease..
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April 22, 2022
This past decade has undoubtedly witnessed an increase in the number of single arm trials submitted to HTA bodies...
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April 7, 2022
Randomized control trials (RCTs) are the gold standard for estimating the efficacy of a treatment. They allow us to..
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April 1, 2022
At the end of every year, scientists from across Cytel’s business units are nominated for Cytel’s Spotlight Awards,..
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March 18, 2022
Real world evidence (RWE) provides a large and growing source of insights into drug uptake and safety. It is..
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January 19, 2022
The past two years have been transformative for Cytel. Most notably, the global COVID-19 pandemic unleashed an..
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December 23, 2021
Cytel blogs bring you debate and discussion of the newest trends in statistics and quantitative strategy. In 2021, our..
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November 23, 2021
A randomized clinical trial (RCT) is the gold standard approach to demonstrate the efficacy and safety of novel..
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November 11, 2021
The value of Real World Evidence (RWE) is well known to many stakeholders, but its full potential for market access and..
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November 4, 2021
The prominent European conference for Health Economics and Outcomes Research (HEOR), ISPOR Europe 2021, is around the..
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October 21, 2021
A number of methods currently exist to measure non-adherence and non-persistence of medical therapies, for improved..
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October 7, 2021
‘Drugs do not work in patients who do not take them,’ said former surgeon general C. Everett Koop. Unfortunately, the..
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September 30, 2021
A complex methodological issue which arises in the production of real-world evidence involves the degree to which..
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September 23, 2021
A complex methodological issue which arises in the production of real-world evidence involves the degree to which..
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May 20, 2021
As more payers and HTA agencies turn to real world data to compare the effectiveness of various treatment effects, two..
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May 13, 2021
Cytel’s HEOR and RWE Expertise has grown quite significantly in the past year. Could you speak a little bit about the..
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May 5, 2021
Cytel’s team of HEOR and RWE experts are all set to make a splash at the Virtual ISPOR on May 17 - 20. Our global..
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April 21, 2021
Two therapies are placed in head-to-head clinical trials when they are compared against each other as opposed to a..
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April 7, 2021
Scientists at Cytel recently published a paper in the Journal of the American Medical Association (JAMA). Among the..
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March 26, 2021
Former Commissioner of the FDA, Dr. Scott Gottlieb, in several public presentations, would bemoan missed chances to..
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February 1, 2021
Cytel’s COVID-19 Trial Tracker continues to provide real time updates to the status of COVID-19 clinical trials..
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January 22, 2021
COVID-19 has transformed the pharmaceutical industry in a manner that few could have predicted only a year ago. One of..
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January 11, 2021
In April 2020, Cytel launched an open-access global COVID-19 Clinical Trial Tracker to help facilitate greater..
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December 21, 2020
2020 has been an unusually difficult year as the global pandemic impacted all of our lives. This year, the Cytel blog..
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November 24, 2020
Virtual ISPOR 2020, held November 16 to 19, presented new opportunities for scientific interaction amongst HEOR..
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November 12, 2020
Cytel and Ingress Health (now a Cytel company) will be contributing to a range of events at Virtual ISPOR EUROPE 2020,..
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November 5, 2020
In oncology, many manufacturers go into niche indications, where there are very specific tumors, and then they opt for..
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November 3, 2020
When an expert statistician is paired with an experienced set of data managers, opportunities to capitalize on..
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October 22, 2020
In this two-part blog series, we interview Bart Heeg, Vice President HEOR and Founder at Ingress Health (A Cytel..
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October 20, 2020
In this interview with Thomas Wilke, Principal Scientist at Ingress-Health (a Cytel company), we talk to him about his..
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October 19, 2020
COVID-19 has created extreme uncertainties -- a dearth of historical information combined with the need for safety,..
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October 14, 2020
A credible evidence base is needed to support and document the economic value of new technologies and therapeutic..
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October 13, 2020
The combination of greater access to electronic health records, bigger electronic claims datasets, and the need for..
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October 7, 2020
With the rise in digital technologies, there has been an explosion in the volume and type of data sources. We can..
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September 25, 2020
Regulators in both the United States and Europe have responded positively to the use of synthetic control arms (SCA)s..
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September 16, 2020
Synthetic control arms (SCA) are virtual trial arms that use historical claims data and observational data to simulate..
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September 10, 2020
Single arm trials are emerging as an accepted way of assessing a new treatment intervention. They establish clinical..
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August 7, 2020
Recently a biotech approached Cytel for support with a Phase 2 Study in oncology. Regulators had requested a natural..
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August 5, 2020
Cytel is conducting two pilot projects on head-to-head comparisons using real world data. These projects in oncology..
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July 23, 2020
Just as there are numerous adaptations that fall within the umbrella of adaptive designs, there are several different..
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February 25, 2020
Over the past decade, a new trend began to emerge, changing the way that clinical trials are conducted. Whereas..
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February 25, 2020
Regulators in both the United States and Europe have responded positively to the use of SCAs in clinical..
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February 20, 2020
It is widely acknowledged among drug developers that one of their most important assets is the data generated during..
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January 22, 2020
In the quest for clinical success, we all strive for evidence packages of the highest quality. If the clinical data is..
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December 10, 2019
In association with Statisticians in the Pharmaceutical Industry (PSI) , UCB and Cytel hosted a symposium on September..
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December 5, 2019
Author: Michael S. Paas, Market Access & Commercialization Expert, Executive at AbbVie and Guest Author at Cytel In..
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November 21, 2019
Author: Michael S. Paas, Market Access & Commercialization Expert, Executive at AbbVie and Guest Author at Cytel In my..
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October 10, 2019
A disease is generally considered to be rare if it affects one patient per 200,000 people (1) and most rare diseases..
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September 12, 2019
"If you went to bed last night as an industrial company, you're going to wake up today as a software and analytics..
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August 23, 2019
In place of collecting data from patients recruited for a trial who have been assigned to the control or..
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August 1, 2019
The term biomarker signature describes the behavior of a set of biomarkers that define a signature to maximize the..
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February 21, 2019
In 2018, Cytel ran a qualitative survey among biostatisticians and programmers on trends in data science and..
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September 10, 2018
The biopharmaceutical and healthcare industries now collect more data than ever before due to advances in the variety..
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June 14, 2018
In this blog, Paul Fardy, Executive Director of Data Management at Cytel shares his thoughts on how the data manager..
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February 28, 2018
There is a consensus in the industry that data on rare diseases is limited, incomplete, and difficult to find or..
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April 28, 2017
In this blog we share a case study in which our statistical consulting team helped a client redesign an oncology..
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