
Perspectives on Enquiry & Evidence
Cytel's blog featuring the latest industry insights.

September 22, 2023
Interest and appetite for master protocols is growing as sponsors consider opportunities in various therapeutic areas...
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December 29, 2022
Top Perspectives Articles of 2022
Perspectives on Enquiry and Evidence explores a wide variety of topics within clinical trial design and data science in...
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December 14, 2022
Accrual When Starting a Platform Trial vs. in a Stand-Alone Trial
When evaluating the efficacy of a candidate investigational therapy, a standard clinical trial paradigm is to conduct a...
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October 5, 2022
Platform Trials, Can they Benefit Animal Studies?
Master protocols and platform clinical trials have become an innovative and efficient approach to testing multiple...
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August 30, 2022
Understanding the Economic Benefits of Platform Trials
Many thanks to Kyle Wathen and Behnam Sharif for their input on this post.
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July 12, 2022
Strategies for Selecting New Indications for a Platform Trial
Thanks to Dr. Kyle Wathen for comments on this blog. The increasing use of platform trials for the testing of a wide...
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June 29, 2022
Platform Trials, Master Protocols, and Challenges in Execution
How can we build an efficient statistical protocol for a clinical trial, if we do not know the therapies that will be...
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January 21, 2022
How to Use and Interpret the Results of a Platform Trial
For our first Winter Weekend Read, Cytel presents How to Use and Interpret the Results of a Platform Trial, a JAMA...
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October 29, 2021
Designing Platform Trials
A platform trial, a type of Master Protocol, is an experimental infrastructure to evaluate multiple treatments and/or...
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October 15, 2021
Applications of Master Protocols in a Global Health Context
Almost 3000 registered trials were performed in COVID-19 and a majority of them have been small and likely...
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May 21, 2021
Use of Bayesian Analysis in Platform Trials: Webinar by Dr. Kyle Wathen
Most of us are familiar with the concept of platform clinical trials as they have gained popularity in the recent...
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December 2, 2020
Program and Portfolio Optimization: A New Paradigm
Significant advances have been made to enhance the efficiency of clinical trial designs. However, the traditional...
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November 10, 2020
Key Design Considerations for Platform Trials
Platform trials are a new type of clinical trials where multiple interventions can be evaluated simultaneously against...
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October 9, 2020
Cyrus Mehta on Increasing the Power of Platform Trials
Even before the era of COVID-19, significant attention was channeled to the overwhelming potential of adaptive MAMS...
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September 30, 2020
A Virtual Event Brought to you by Cytel and Novartis on Innovations
Today, there is a need for advanced quantitative techniques to combine all available information for better decision...
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September 28, 2020
Advantages of platform designs for investigating COVID-19 therapies
Cytel has recently designed and implemented the TOGETHER Trials, funded by the Bill & Melinda Gates Foundation to...
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September 21, 2020
Novel Adaptive Platform Trial for COVID-19 Therapies
Cytel has designed and implemented a novel adaptive platform trial for early stage COVID-19. The severity of the...
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June 24, 2020
Webinar - Practical Model-based Approaches for Phase I Oncology Trials
Last week, Cytel conducted its third webinar in the new introductory webinar series on Complex Innovative Trial...
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June 15, 2020
Significance of Bayesian Model-Based Approaches in Oncology Trials: An Interview with Dr. Satrajit Roychoudhury
Cytel conducted a webinar with Dr. Satrajit Roychoudhury, Senior Director, Statistical Research and Data Science...
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June 11, 2020
Adaptive Bayesian Methods: The Secret Weapon in COVID-19 Vaccine Development
A recent Cytel panel led by Vice President of Strategic Consulting Natalia Muhlemann evaluated the role that Bayesian...
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June 1, 2020
Webinar Replay: Innovative Drug Development at a Glance
In a recent interview with Cytel, Zoran Antonijevic, longstanding chair and leader of the DIA Adaptive Design...
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May 18, 2020
Interview with Zoran Antonijevic on Adaptive Design Methods
In this blog, we speak with Zoran Antonijevic, longstanding chair and leader of the DIA Adaptive Design Scientific...
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May 1, 2020
Weekly Insights from Cytel's COVID-19 Trial Tracker
There are currently 665 trials registered at Cytel’s COVID-19 Trial Tracker, a jump of over 100 trials in the past two...
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April 14, 2020
Early Insights from Cytel’s New COVID-19 Trial Tracker
Last week Cytel launched a COVID-19 Trial Tracker, an Open Access tool to track the global response to the coronavirus...
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March 12, 2020
Interview with Jay Park: The present and future of Master Protocols
In September 2018, the FDA provided a draft guidance on master protocols reflecting an increased interest in these...
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