How to handle conservativeness of Exact p-value?

Posted by Ashwini Joshi

Sep 18, 2017 7:38:45 AM

 

By Ashwini Joshi

For small sample data or rare events data, exact non-parametric tests perform better than asymptotic tests. But they come with the disadvantage of conservativeness. Many corrections have been suggested to reduce this conservativeness but none of them solve the problems entirely.  StatXact provides various methods of computing exact p-values. Depending upon the problem at...

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Topics: StatXact, Exact Tests, exact statistics, Small Sample Sparse Data, biostatistics, p value


How can the CMO/Biostatistician connection improve clinical development?

Posted by Cytel

Jun 7, 2016 8:00:00 AM

 At the recent CMO Summit East  James ( Jim) Bolognese, Cytel’s Senior Director of Strategic Consulting, and Lou Vaickus,MD, FACP, Founder and President of aktaPD jointly explored how the critical connection between a CMO and a biostatistician can help enhance communication with internal and external stakeholders, ensure patient safety and ultimately improve clinical development efficiency....

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Topics: Clinical Development Strategy, go-no-go, clinical development, biostatistics, p value


What's the Value of P?

Posted by Cytel

Mar 23, 2016 9:30:00 AM

“How many statisticians does it take to ensure at least a 50% chance of a disagreement about p-values?” 

So questions George Cobb of Mt. Holyoke College in  his commentary on  the ASA’s 7th March ‘Statement  on P Values: context, process and purpose’

The association took the unprecedented step of publishing the statement following a long litany of criticism of misuse of the P value. This included...

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Topics: Bayesian Methods, p value


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