Perspectives on Enquiry & Evidence
Cytel's blog featuring the latest industry insights.
March 13, 2024
Group sequential clinical trial designs — a type of adaptive clinical trial design — have emerged as a powerful tool in...
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February 20, 2024
Negative Binomial Distribution in Group Sequential Designs
In clinical trials based on count data, the aim is to compare independent treatment groups in terms of the rate of...
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February 15, 2022
Measuring Estimates and Confidence Intervals in Adaptive settings?
As the use of advanced and innovative clinical trial designs continue to rise, sponsors often wonder which estimation...
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January 29, 2021
Computation and Clinical Trial Design: New Directions
Historically, advances in the statistical design of clinical trials have accompanied progress within the science and...
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October 1, 2020
Improve Trial Design with Sequential Design and Sample Size
Methods involving Group Sequential Designs are one of the earliest deviations from a traditional two-arm clinical trial...
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September 29, 2020
The New Horizons Series: Adaptive Multi-arm Multi-stage Clinical Trials
Innovation in trial designs are offering new routes forward for organizations of any size. They are now also aligned...
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September 17, 2020
East Alloy: Accelerating the pace of innovation
Keeping up with the rapid pace of clinical development means that we need to adopt the innovative or computationally...
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August 31, 2020
Adopt innovative and computationally intensive designs with East Alloy
Pantelis Vlachos, Principal, Strategic Consultant at Cytel, conducted a webinar to introduce the capabilities of East...
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July 22, 2020
Access Sustainable, Verified Innovation with East Alloy
Cytel brings to you a new blog series on technology and Bayesian decision-making by Pantelis Vlachos,...
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June 10, 2020
Group Sequential Designs and Sample Size Re-estimation
Cytel is conducting a webinar series that introduces biostatisticians to some of the more commonly used complex...
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May 27, 2020
Group Sequential Designs and Sample Size Re-estimation
In this blog, we speak with Christopher Jennison, Professor of Statistics at the University of Bath, UK. Professor...
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February 15, 2018
A Gatekeeping Procedure to Test a Group Sequential Design
A recent publication in Biometrics ‘A Gatekeeping Procedure to Test a Primary and a Secondary Endpoint in a Group...
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April 28, 2016
Adaptive Designs in Practice
Adaptive Designs in Practice: Interview with NIHR Research Fellow Munya Dimairo NIHR and University of Sheffield...
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February 3, 2015
Clinical Development & Statistical Methodology for Cardiovascular Risk Assessment
A new publication co-authored by Cytel Co-Founder and President Cyrus Mehta considers a range of clinical development...
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