
Perspectives on Enquiry & Evidence
Cytel's blog featuring the latest industry insights.

June 8, 2022
Clinical researchers, seeking to understand the statistical benefits of a common Phase 2 oncology design, now have a...
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June 7, 2022
Continuous Monitoring for Blinded Sample Size Reestimation
In most instances of blinded sample size re-estimation, the timing of the interim analysis that determines whether the...
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April 5, 2022
Time Check: Developing New Therapeutics
Hello! I’m delighted to pen my inaugural blog post here as Cytel’s Chief Medical Officer. In this series, we’ll explore...
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May 12, 2020
Oncology Trial Design & Development Webinar Series
In our previous blog, “Remote Working Arrangement – How to get it right?”, we talked about how the need for social...
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May 7, 2020
COVID-19: Trials, Designs and Tools for Promising Results - A Virtual Panel Discussion
An extraordinary amount of global research is underway as the COVID-19 pandemic continues to evolve and spread...
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May 5, 2020
Webinar: A Clinician’s Perspective on Cancer Drugs Development
Cytel's team of oncology trial design and advanced analytics experts are hosting a series of complimentary webinars...
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April 23, 2020
A Clinician’s Perspective on Cancer Drugs Development
Cytel is hosting a webinar, “A Clinician’s Perspective on Cancer Drugs Development”, on April 28, 2020. Our speaker,...
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February 28, 2019
Statistical Approaches to Overcome Challenges in Rare Disease Development
In honor of Rare Disease Day 2019 we share a new Cytel podcast featuring Cytel Strategic Consultant Ursula Garczarek...
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January 10, 2019
Podcast: Overcoming Phase 1 Development Challenges
Nand Kishore Rawat is a Director and Head, Early Phase Biostatistics based in the King of Prussia, PA Cytel office. We...
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December 5, 2018
Creating a Common Language: Forging Statistical and Clinical Collaborations
In this blog, Paul Terrill, Director of Strategic Consulting at Cytel outlines his blueprint for ensuring smooth...
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October 23, 2018
Career Perspectives: Interview with Munshi Imran Hossain, Senior Data Scientist
Cytel data scientists apply advanced statistical techniques including predictive modeling of biological processes and...
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September 20, 2018
Career Perspectives: Interview with Adam Hamm, Director of Biostatistics
At Cytel we believe that expert statistical input has the power to shape the future of clinical development: de-risking...
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August 23, 2018
Career Perspectives: Interview with Meredith Alm, Manager, QA Compliance
Cytel has grown significantly over the last 30 years, with operations across North America, Europe, and India. All of...
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August 8, 2018
How can a strategic pharmacometrics consultant add value to your team?
We have written on the blog in the past about the value that a statistical consultant can bring to your team, and to...
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August 1, 2018
Building interactive web applications using R Shiny
By Gordhan Bagri and Munshi Imran Hossain with H A S Shri Kishore Shiny (from RStudio) is one of the most popular R...
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July 24, 2018
Career Perspectives: Interview with Sam Hsiao, Associate Director, Strategic Consulting
At Cytel our strategic consulting team works on a wide range of projects including: Identifying the best clinical trial...
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July 18, 2018
Recent Publication: On shapes of ADR report accumulation data
A recent article published by Cytel authors Samadhan Ghubade, Sharayu Paranjpe, Kushagra Gupta, Anil Gore and colleague...
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March 16, 2018
Career Perspectives: Interview with Benjamin Esterni, Principal Biostatistician
At Cytel we believe that expert statistical input has the power to shape the future of clinical development: de-risking...
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February 13, 2018
Career Perspectives: Interview with Ursula Garczarek, Associate Director - Strategic Consulting
Our strategic consulting team work on projects such as: Identifying the best clinical trial design, implementing...
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May 22, 2017
Jim Bolognese named 2017 American Statistical Association Fellow
James (Jim) Bolognese, Senior Director, Strategic Consulting, Clinical Services at Cytel Inc. was named a 2017 fellow...
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January 30, 2017
Accelerating development with combined SAD/MAD approach
Single ascending dose (SAD) and multiple ascending dose (MAD) studies are typically the first in human studies. They...
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January 23, 2017
How to get the regulatory green light for your adaptive design?
As a group, Cytel had over 40 successful regulatory interactions last year, many of which supported approvals for...
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December 13, 2016
Harnessing the power of R API to extend software applications
In the complex world of trial design and data analysis biostatisticians and data scientists need to ensure they are...
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December 2, 2016
Innovative Phase 3 Adaptive Enrichment Design in Oncology
At a recent Pfizer/ Cytel seminar on rare disease and oncology development, Cytel’s Lingyun Liu presented innovative...
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November 18, 2016
Case Study: Dose-response modeling informs Phase 2 ulcerative colitis study design
Challenge Our client had the following key questions which they wanted our pharmacometrics group to address for an...
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September 13, 2016
Case Study:Exposure Response Modeling in Hematology
Exposure-response data gained from clinical studies can provide a basis for model-based analysis and simulation,...
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September 9, 2016
Case Study:Seamless Phase 2/3 Design in Rare Disease
Challenge: Our client, an emerging biotechnology company, was preparing for the next stage of development for their...
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February 10, 2015
How to Shorten a Cardiovascular Outcome Trial By Two Years
Cardiovascular outcome trials (CVOTs) have earned the reputation of being the untamable behemoths of the clinical...
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October 14, 2014
7 Reasons to Add a Statistical Consultant to Your Team
We are often asked how statistical consultants can add value to the clinical development process. What do they...
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September 4, 2014
Adaptive Designs for Evidence Based Oncology: Insights from the Experts
Imagine if we were to count the number of possible reasons that investigators might have for monitoring a biomarker...
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September 2, 2014
Impact of Study Design and Development Strategy on Pharmaceutical Programs and Portfolios
As more clinical trials make use of adaptive designs, investors have come to realize that high quality trial designs...
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