
Perspectives on Enquiry & Evidence
Cytel's blog featuring the latest industry insights.

January 27, 2022
As a part of Cytel’s 10 Year Anniversary of the Promising Zone Design, Cytel hosted a quiz on “Keeping the Promise” –...
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December 20, 2021
Approaches in Adaptive Group Sequential Clinical Trials
The promising zone design is an adaptive design which allows for sample size re-estimation based on the results of an...
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December 14, 2021
Is Promising Zone Design Optimal?
In traditional clinical trial design, the sample size is often determined to detect the target treatment effect with...
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December 8, 2021
Conditional Powers Vs Bayesian Predictive Power for Adaptive Sample Size Reassessment
Despite the debate in the scientific community on adaptive sample size reassessment (SSR), noteworthy developments have...
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November 15, 2021
Optimal Promising Zone Designs: What Biotechs Need to Know
Since its first publication ten years ago, Cyrus Mehta and Stuart Pocock’s Promising Zone Design for sample size...
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November 8, 2021
Keeping the Promise: Ten Year Anniversary of the Promising Zone Design
Ten years ago Cytel co-founder Professor Cyrus Mehta and Professor Stuart Pocock of the London School of Hygiene and...
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January 16, 2017
Adaptive Design Approaches from Cardiovascular Clinical Trialists Forum
The Global Cardiovascular Clinical Trialists Forum is a key event bringing together leading experts from across the...
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June 16, 2016
Determining the future course of your trial
Predicting the course of a clinical trial is something which people will always want to do-whether for statistical...
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March 19, 2015
How to Plan Interim Looks in Adaptive Clinical Trials: 3 Strategies
A well-timed interim analysis can generally supply added benefits to the operational and administrative aspects of a...
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