September 15, 2021
There is recognized heterogeneity within any given tumor‐type from patient to patient (inter‐patient heterogeneity),...
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July 2, 2021
Popular statistical designs, such as CRM (O’Quigley et al., 1990), mTPI-2 (Guo et al., 2017), and i3+3 (Liu et al.,...
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June 9, 2021
When selecting clinical trial designs, how many design options should a sponsor explore? Would a sponsor feel more...
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June 2, 2021
For many decades the Pareto Frontier has been employed by actors in the private sector to evaluate and understand the...
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May 28, 2021
Advancements in biomarkers and momentum in precision medicine has paved the foundation for complex studies like basket...
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May 14, 2021
When developing clinical strategy, applying familiar business principles to the specific requirements of clinical...
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April 28, 2021
Recently, Cytel co-founder Professor Cyrus Mehta noted that, “Clinical trial design selection is too much like an art,...
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April 20, 2021
For much of the past three decades, even as methodologies for clinical trial design have advanced and refined, the idea...
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April 14, 2021
In the era of modern clinical development, several companies are turning towards novel and innovative approaches such...
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March 18, 2021
Over the past ten years High-Performance Computing (HPC) has transformed medical research through advances in genomics,...
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February 19, 2021
C-Suite and R&D Decision-Makers are always striving to make evidence-driven decisions. Yet the rules by which evidence...
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February 18, 2021
In the last few years, there has been a growing interest in historical borrowing or augmented trials. There is an...
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February 2, 2021
As the use of master protocols becomes more prevalent in drug development, Bayesian methods are extensively used to...
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January 26, 2021
Bayesian models offer a flexible way of incorporating historical controls in the analysis of trial data (whether single...
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December 17, 2020
As Chief Scientific Officer, Dr. Yannis Jemiai plays a pivotal role in maintaining Cytel’s well-established reputation...
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December 16, 2020
As we prepare to close the door on 2020, we asked Pantelis Vlachos, Principal/Strategic Consultant for Cytel, to share...
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December 15, 2020
When designing clinical trials, biostatisticians and clinical development teams are often faced with a conundrum. Given...
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December 9, 2020
As a part of Cytel’s Advanced Design Framework, a new Framework for the statistical design of clinical trials, Cytel...
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December 3, 2020
Increasing Clinical Development Productivity Using Statistics and Cloud-Computing The need for Re-imagining Clinical...
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November 18, 2020
The current state of the clinical trials industry faces a challenge that was only hypothetical three or four years ago....
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November 17, 2020
As a part of Cytel’s "New Horizons Webinar Series", Alind Gupta, Senior Data Scientist, presents case studies from his...
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November 16, 2020
MUCE is a Bayesian solution for cohort expansion trials where multiple dose(s) and multiple indication(s) are tested in...
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November 11, 2020
The widespread use of cloud-computing has altered the clinical trial design process. Whereas three or four years ago,...
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November 4, 2020
Cytel has recently revealed its Advanced Design Framework, a method developed by Cytel’s thought leaders that draws on...
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October 29, 2020
Cytel has recently revealed its Advanced Design Framework, a method developed by Cytel’s thought leaders that draws on...
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October 26, 2020
Pharmaceutical and biotech companies are under pressure to deliver more and deliver faster with fewer resources. The...
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October 21, 2020
Cytel has recently revealed its Advanced Design Framework, a method developed by Cytel’s thought-leaders after a decade...
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October 15, 2020
For over a decade, advanced trial design techniques have promised efficient trials with accelerated timelines,...
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October 1, 2020
Methods involving Group Sequential Designs are one of the earliest deviations from a traditional two-arm clinical trial...
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September 29, 2020
Innovation in trial designs are offering new routes forward for organizations of any size. They are now also aligned...
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September 9, 2020
Cytel’s co-founder, Nitin Patel, conducted a webinar on designing clinical trials from a program-level perspective. His...
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September 4, 2020
On Friday September 11, Cyrus Mehta, co-founder of Cytel, will be delivering a talk to the Heart Failure Collaboratory,...
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August 31, 2020
Pantelis Vlachos, Principal, Strategic Consultant at Cytel, conducted a webinar to introduce the capabilities of East...
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August 26, 2020
As Chief Scientific Officer, Dr. Yannis Jemiai plays a pivotal role in maintaining Cytel’s well-established reputation...
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August 25, 2020
It is important to take a strategic approach to clinical development in order to minimize the potential for Phase 3...
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July 27, 2020
Cytel is conducting a webinar series on complex innovative trial designs. Dr. Thomas Burnett, Senior Research Associate...
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July 13, 2020
Cytel is hosting a complimentary webinar series that introduces biostatisticians and other members of the development...
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July 7, 2020
Having its roots in the seminar rooms of the Dana Farber Cancer Institute, Cytel has a long record of establishing new...
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June 10, 2020
Cytel is conducting a webinar series that introduces biostatisticians to some of the more commonly used complex...
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May 29, 2020
At the close of May 2020, we have about 500 new trials globally but trends in trial design and choice of therapies...
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May 27, 2020
In this blog, we speak with Christopher Jennison, Professor of Statistics at the University of Bath, UK. Professor...
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May 12, 2020
In our previous blog, “Remote Working Arrangement – How to get it right?”, we talked about how the need for social...
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May 7, 2020
There are now over 950 trials registered, which means that 250 new trials were registered in the past week. Only 540 of...
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April 29, 2020
In our previous blog, we spoke with Alind Gupta, who works as a Machine Learning Researcher at Cytel in Canada. The...
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April 20, 2020
Cytel is hosting a webinar on Transparent Machine Learning in Oncology, on April 21, 2020. Our speaker, Alind Gupta,...
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March 31, 2020
Since 1953, when the discovery of the structure of DNA was made, we have seen great advancements in genomics....
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January 16, 2020
January’s Cytel Trial Design Innovations (CTDI) Webinar Series will feature Biostatistician and pioneering Bayesian...
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November 5, 2019
Cytel is delighted to have Kannan Natarajan speaking at the “Complex Innovative Trial Design Symposium and East User...
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August 23, 2019
In place of collecting data from patients recruited for a trial who have been assigned to the control or...
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July 22, 2019
Health economics and adaptive design methods share common ground in that they both aim to support more efficient and...
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June 14, 2019
This article was originally published as part of a series by pharmaphorum in association with Cytel and is reproduced...
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February 8, 2019
A 2018 publication in the Biometrical Journal by Cytel’s Cyrus Mehta, Lingyun Liu and Sam Hsiao, ‘Optimal Promising...
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November 5, 2018
Cytel biostatisticians Cyrus Mehta and Lingyun Liu, together with Charles Theuer, CEO of TRACON Pharmaceuticals have...
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September 27, 2018
In this blog, we talk with Heiko Götte, Senior Expert Biostatistician at Merck about his upcoming presentation at...
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May 23, 2018
Our Industry Voices series showcases our clients’ innovative work and breakthrough therapeutics in oncologic...
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May 16, 2018
Our Industry Voices series showcases our clients’ innovative work and breakthrough therapeutics in oncologic...
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May 9, 2018
As we prepare to head to ASCO in under a month's time, we are pleased to share a new ebook that showcases some key...
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