
Perspectives on Enquiry & Evidence
Cytel's blog featuring the latest industry insights.

August 28, 2023
A clinical development plan — a comprehensive strategy for developing an investigational product through regulatory...
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October 28, 2022
Measuring Robustness of Clinical Trial Designs with Pressure Tests
Integrating the “pressure testing” of clinical trial designs into the process of creating a strong clinical trial...
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May 24, 2022
Leveraging Advanced Statistical Software to Optimize Clinical Development
Traditionally, clinical trials are expensive, long in duration, and have low success rate. But with the advent of rich...
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April 27, 2022
Reinventing Clinical Trial Design: Digital Development
New medicines and devices under development live and die on the strength of their clinical data. An asset’s journey is...
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March 23, 2022
How to Use Historical Data to Mitigate Clinical Trial Risk
For over a decade, the number one reason cited for trial discontinuity has been challenges associated with recruitment...
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January 19, 2022
What’s Ahead for Clinical Trial Design?
The past two years have been transformative for Cytel. Most notably, the global COVID-19 pandemic unleashed an...
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November 30, 2021
Dr. Julia Edwards Findings Promising Zone Designs
The aim of any clinical research is to detect the actual difference in treatment effect between two groups (power) and...
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October 14, 2021
Weighting and Prioritization for Trial Selection: New Webinar
When choosing the optimal clinical trial design for a given study, sponsors face critical questions like choice of...
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June 30, 2021
Mathematical Methods for Clinical Trial Financial Strategy
When Cyrus Mehta introduced the Promising Zone Design over a decade ago, the new statistical method not only...
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June 23, 2021
Eliminating Underperforming Clinical Trial Designs
Much of the discussion about clinical trial design considers methods to optimize performance characteristics and...
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June 18, 2021
Use of Scoring Functions for Clinical Trial Optimization
Next week’s PSI Conference will feature Dr. Yannis Jemiai speaking on the use of Scoring Functions in the re-imagined...
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May 14, 2021
Starting the Conversation Early: Incorporating Business Considerations in Optimal Selection of Trial Design
When developing clinical strategy, applying familiar business principles to the specific requirements of clinical...
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April 28, 2021
Trial Selection: From Art to Science
Recently, Cytel co-founder Professor Cyrus Mehta noted that, “Clinical trial design selection is too much like an art,...
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April 20, 2021
New Dimensions of Clinical Trial Optimization
For much of the past three decades, even as methodologies for clinical trial design have advanced and refined, the idea...
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March 19, 2021
5 Steps to Regulatory Success with Wearables Designs
The use of wearable and digital technology requires considerations for both drugs and devices regulations, and...
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March 18, 2021
Computing & Statistics: Are You Ready for the Industry Transformation?
Over the past ten years High-Performance Computing (HPC) has transformed medical research through advances in genomics,...
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March 12, 2021
Wearables: Translating raw data to actionable information
With wearables likely to become a regular part of clinical trial design, statisticians could benefit by familiarizing...
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March 11, 2021
Data and analysis in Modern Oncology Clinical Development
In the recent years, Oncology trials are seeing a technological shift that is expected to make them faster and more...
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February 25, 2021
Use of Wearables in Confirmatory Clinical Trials
The convergence of several distinct trends has made wearables an increasingly attractive option for use in confirmatory...
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February 19, 2021
Selecting Your Next Clinical Trial Design Using Quantitative Methods
C-Suite and R&D Decision-Makers are always striving to make evidence-driven decisions. Yet the rules by which evidence...
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February 11, 2021
The biostats and clinical overview of a growing clinical strategy
The past two years have witnessed a heightened interest in the use of wearables in clinical development. The unexpected...
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