The Cytel Blog: Perspectives on Enquiry & Evidence

There is recognized heterogeneity within any given tumor‐type from patient to patient (inter‐patient heterogeneity),..

Program and portfolio optimization creates a framework throughout the course of the clinical development journey, that..

Conducting a transparent, targeted and robust benefit-risk assessment of a new drug or product is one of the most..

Popular statistical designs, such as CRM (O’Quigley et al., 1990), mTPI-2 (Guo et al., 2017), and i3+3 (Liu et al.,..

The main challenge associated with the development of therapies for rare diseases is typically the small study sample..

Bayesian methods have been playing a key role in transforming clinical research in therapeutic areas such as oncology..

Bayesian methods allow for the incorporation of prior knowledge, in terms of either expert opinion from clinicians or..

Advancements in biomarkers and momentum in precision medicine has paved the foundation for complex studies like basket..

Most of us are familiar with the concept of platform clinical trials as they have gained popularity in the recent..