July 27, 2022
Written by Jing Ping Yeo and Charles Warne Adaptive designs are studies that “include a prospectively planned...
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June 14, 2022
Suppose you had to choose six clinical trials intended for registration with regulatory agencies, only six, to explain...
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May 3, 2022
In 2005, Pfizer launched a Phase 1 trial for the kinase inhibitor crizotinib. Six years later, it was approved, thanks...
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November 30, 2021
The aim of any clinical research is to detect the actual difference in treatment effect between two groups (power) and...
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March 9, 2021
When statistical sciences were in their infancy, the communicative benefits of statistics were widely touted. Thousands...
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February 12, 2021
In recent times, Single arm trials are being increasingly used to assess new treatment interventions. They establish...
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February 4, 2021
The past decade has witnessed the rise of simulations-based clinical trial optimization in a manner unimaginable to...
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February 2, 2021
As the use of master protocols becomes more prevalent in drug development, Bayesian methods are extensively used to...
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January 29, 2021
Historically, advances in the statistical design of clinical trials have accompanied progress within the science and...
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December 21, 2020
2020 has been an unusually difficult year as the global pandemic impacted all of our lives. This year, the Cytel blog...
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December 17, 2020
As Chief Scientific Officer, Dr. Yannis Jemiai plays a pivotal role in maintaining Cytel’s well-established reputation...
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December 15, 2020
When designing clinical trials, biostatisticians and clinical development teams are often faced with a conundrum. Given...
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December 9, 2020
As a part of Cytel’s Advanced Design Framework, a new Framework for the statistical design of clinical trials, Cytel...
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December 3, 2020
Increasing Clinical Development Productivity Using Statistics and Cloud-Computing The need for Re-imagining Clinical...
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November 18, 2020
The current state of the clinical trials industry faces a challenge that was only hypothetical three or four years ago....
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November 11, 2020
The widespread use of cloud-computing has altered the clinical trial design process. Whereas three or four years ago,...
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November 4, 2020
Cytel has recently revealed its Advanced Design Framework, a method developed by Cytel’s thought leaders that draws on...
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October 29, 2020
Cytel has recently revealed its Advanced Design Framework, a method developed by Cytel’s thought leaders that draws on...
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October 27, 2020
Cytel recently conducted a webinar on Bayesian Dose-finding Designs for Modern Drug Development, presented by Dr. Yuan...
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October 26, 2020
Pharmaceutical and biotech companies are under pressure to deliver more and deliver faster with fewer resources. The...
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October 21, 2020
Cytel has recently revealed its Advanced Design Framework, a method developed by Cytel’s thought-leaders after a decade...
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October 15, 2020
For over a decade, advanced trial design techniques have promised efficient trials with accelerated timelines,...
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October 12, 2020
Cytel and Novartis are together hosting a complimentary Bayesian Virtual Symposium and an Interactive 7-part workshop....
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October 1, 2020
Methods involving Group Sequential Designs are one of the earliest deviations from a traditional two-arm clinical trial...
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September 29, 2020
Innovation in trial designs are offering new routes forward for organizations of any size. They are now also aligned...
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September 9, 2020
Cytel’s co-founder, Nitin Patel, conducted a webinar on designing clinical trials from a program-level perspective. His...
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September 4, 2020
On Friday September 11, Cyrus Mehta, co-founder of Cytel, will be delivering a talk to the Heart Failure Collaboratory,...
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August 26, 2020
As Chief Scientific Officer, Dr. Yannis Jemiai plays a pivotal role in maintaining Cytel’s well-established reputation...
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August 25, 2020
It is important to take a strategic approach to clinical development in order to minimize the potential for Phase 3...
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July 13, 2020
Cytel is hosting a complimentary webinar series that introduces biostatisticians and other members of the development...
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June 10, 2020
Cytel is conducting a webinar series that introduces biostatisticians to some of the more commonly used complex...
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May 27, 2020
In this blog, we speak with Christopher Jennison, Professor of Statistics at the University of Bath, UK. Professor...
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January 30, 2020
The Cytel Trial Design Innovations (CTDI) Webinar Series recently hosted a webinar on designing event-based studies....
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January 16, 2020
January’s Cytel Trial Design Innovations (CTDI) Webinar Series will feature Biostatistician and pioneering Bayesian...
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November 5, 2019
Cytel is delighted to have Kannan Natarajan speaking at the “Complex Innovative Trial Design Symposium and East User...
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November 12, 2018
In this blog, we talk with Robert Greene, Founder and President of the HungerNDThirst Foundation, about his upcoming...
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November 5, 2018
Cytel biostatisticians Cyrus Mehta and Lingyun Liu, together with Charles Theuer, CEO of TRACON Pharmaceuticals have...
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October 23, 2018
Cytel data scientists apply advanced statistical techniques including predictive modeling of biological processes and...
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October 5, 2018
We are delighted that Stephen Senn will be joining us at the EUGM on November 14th and 15th in Darmstadt, Germany. In...
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September 27, 2018
In this blog, we talk with Heiko Götte, Senior Expert Biostatistician at Merck about his upcoming presentation at...
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September 20, 2018
At Cytel we believe that expert statistical input has the power to shape the future of clinical development: de-risking...
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August 31, 2018
JSM 2018, ASA’s annual gathering of over 6500 attendees attracted statisticians and data scientists to the beautiful...
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August 23, 2018
Cytel has grown significantly over the last 30 years, with operations across North America, Europe, and India. All of...
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August 15, 2018
Cytel’s 7th East User Group Meeting (EUGM) will take place on November 14 & 15, 2018 at Merck in Darmstadt, Germany,...
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July 24, 2018
At Cytel our strategic consulting team works on a wide range of projects including: Identifying the best clinical trial...
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July 2, 2018
A number of the Cytel team were in Amsterdam, 3rd- 6th June 2018 for the PSI Conference. This year’s conference was...
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March 16, 2018
At Cytel we believe that expert statistical input has the power to shape the future of clinical development: de-risking...
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February 13, 2018
Our strategic consulting team work on projects such as: Identifying the best clinical trial design, implementing...
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October 31, 2017
As part of Cytel's new Trial Innovations Webinar Series, Pat Mitchell, Statistical Science Director at AstraZeneca...
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October 27, 2017
In this blog, we share the second part of our interview with Bob Beckman, about a design concept for a confirmatory...
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July 11, 2017
The Adaptive Designs and Multiple Testing Procedures Workshop (ADMTP), the first joint meeting of the Adaptive Designs...
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May 22, 2017
James (Jim) Bolognese, Senior Director, Strategic Consulting, Clinical Services at Cytel Inc. was named a 2017 fellow...
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April 25, 2017
At a recent conference Adam Hamm, Director Biostatistics at Cytel, presented his thoughts on Best Practices and...
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April 11, 2017
In a January 2017 paper (1), the FDA reviewed 22 case studies where promising Phase 2 trials did not result in...
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March 29, 2017
With an increasing interest in platform designs and other innovative designs that involve multiple comparisons over...
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January 30, 2017
Single ascending dose (SAD) and multiple ascending dose (MAD) studies are typically the first in human studies. They...
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January 23, 2017
As a group, Cytel had over 40 successful regulatory interactions last year, many of which supported approvals for...
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January 16, 2017
The Global Cardiovascular Clinical Trialists Forum is a key event bringing together leading experts from across the...
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December 15, 2016
In April, we interviewed NIHR research fellow Munya Dimairo about the paper, ‘Adaptive designs undertaken in clinical...
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November 21, 2016
While adaptive designs can deliver significant benefits to clinical development- including ethical benefits for...
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October 7, 2016
Adaptive designs have the potential to accelerate clinical development, and improve the probability of trial success....
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October 5, 2016
While some progress has been made in terms of scientific development in Neuroscience and Neuropsychiatry indications,...
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September 29, 2016
A paper "Best practices case studies for 'less well-understood' Adaptive designs", has been published by the DIA...
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September 7, 2016
In the 2010 draft FDA ‘Guidance for Industry on Adaptive Design Clinical Trials for Drugs and Biologics', the agency...
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August 23, 2016
At the recent JSM meeting in Chicago, Cytel's Jim Bolognese presented the results of work he has conducted evaluating...
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August 17, 2016
Following the recent publication of their review article Adaptive Designs for Clinical Trials in the New England...
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August 9, 2016
At the recent JSM Meeting, Cytel’s Yannis Jemiai presented the case study of the VALOR trial which used a promising...
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July 18, 2016
In order for adaptive designs to reach their potential, it’s critical that knowledge is effectively dissemirnated...
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June 16, 2016
Predicting the course of a clinical trial is something which people will always want to do-whether for statistical...
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April 28, 2016
Adaptive Designs in Practice: Interview with NIHR Research Fellow Munya Dimairo NIHR and University of Sheffield...
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