
Perspectives on Enquiry & Evidence
Cytel's blog featuring the latest industry insights.

February 22, 2022
When determining the best possible statistical design for a particular trial, large pharmaceuticals and small biotechs..
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February 15, 2022
Measuring Estimates and Confidence Intervals in Adaptive settings?
As the use of advanced and innovative clinical trial designs continue to rise, sponsors often wonder which estimation..
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January 27, 2022
Winners of The Promising Zone Quiz
As a part of Cytel’s 10 Year Anniversary of the Promising Zone Design, Cytel hosted a quiz on “Keeping the Promise” –..
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December 20, 2021
Approaches in Adaptive Group Sequential Clinical Trials
The promising zone design is an adaptive design which allows for sample size re-estimation based on the results of an..
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December 14, 2021
Is Promising Zone Design Optimal?
In traditional clinical trial design, the sample size is often determined to detect the target treatment effect with..
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December 8, 2021
Conditional Powers Vs Bayesian Predictive Power for Adaptive Sample Size Reassessment
Despite the debate in the scientific community on adaptive sample size reassessment (SSR), noteworthy developments have..
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November 15, 2021
Optimal Promising Zone Designs: What Biotechs Need to Know
Since its first publication ten years ago, Cyrus Mehta and Stuart Pocock’s Promising Zone Design for sample size..
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November 8, 2021
Keeping the Promise: Ten Year Anniversary of the Promising Zone Design
Ten years ago Cytel co-founder Professor Cyrus Mehta and Professor Stuart Pocock of the London School of Hygiene and..
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September 14, 2021
Career Perspectives: Interview with Alyssa Biller, Senior Solutions Consultant
Alyssa Biller is a Senior Solutions Consultant at Cytel and currently plays a primary role in onboarding customers for..
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