Perspectives on Enquiry & Evidence
Cytel's blog featuring the latest industry insights.
October 29, 2015
A common challenge of working with small sample sizes is determining proper bias correction methods when evaluating a...
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December 9, 2014
Drug Supply Planning for Dose-Ranging Adaptive Trials
When planning a conventional trial, one can anticipate the drug supply necessary for the trial by determining how the...
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November 6, 2014
Translational Statistics: How to Move Beyond the Comfort Zone
Professor LJ Wei holds that rules are for lawyers, not (necessarily) clinicians. When designing modern clinical trials,...
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November 4, 2014
New Exploratory Trial Method Translates into Better Financial Strategy
A key stage of exploratory drug development is implementing a proof-of-concept study to demonstrate the safety of a...
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October 28, 2014
Adaptive Dose Finding Using Toxicity Probability Intervals
Phase 1 oncology trials typically use either rule-based methods or model-based methods to determine the most acceptable...
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July 1, 2014
'Multivariate Approaches for Risk-Based Monitoring' An Adaptive Design (Slides Attached)
A recent Cytel Seminar on Adaptive Statistical Designs featured a talk by Michael Elashoff (Patient Profiles) on...
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June 26, 2014
Adaptive Designs for Precision Medicine: A Look at Pfizer
The rise of biomarker based treatments in oncology has meant a reconceptualization of what constitutes a particular...
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May 5, 2014
The Perils of Poor Recruitment
A new JAMA study on discontinued randomized trials in Switzerland, Germany and Canada, reports that poor recruitment...
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