Adaptive Designs for Evidence Based Oncology: Insights from the Experts

Posted by Esha Senchaudhuri

Sep 4, 2014 1:10:00 PM

Imagine if we were to count the number of possible reasons that investigators might have for monitoring a biomarker during a clinical trial, and multiply that number by the number of possible adaptive designs available for such investigation. We would naturally assume that whatever the number, it would be rather large. This poses an interesting question for a sponsor of an adaptive clinical...

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Topics: Access to Paper PDF, Dose-Escalation, Cytel Strategic Consulting, Adaptive Clinical Trials


Backward Image Confidence Intervals for Adaptive Group Sequential Designs (Full Article Attached)

Posted by Esha Senchaudhuri

Aug 14, 2014 8:00:00 AM

Cytel statisticians are looking foward to attending the Conference of the International Society for Clinical Biostatistics, which will be held in Vienna during the week of August 24th. Members of Cytel will be contributing to four sessions at this conference, including an invited talk on innovation entitled 'Beyond Wild Horses: Developing Innovation at Cytel.' They will also be contributing to a...

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Topics: Cyrus Mehta, Access to Paper PDF, Adaptive Clinical Trials


Mehta Publishes Article on Adaptive Designs for Biomarker Driven Population Enrichment in Oncology

Posted by Esha Senchaudhuri

Jul 10, 2014 1:53:00 PM

Complexities with identifying suitable test populations in oncology studies contribute significantly to the 60% attrition rate in Phase III trials. Cyrus Mehta, (President of Cytel) has recently authored a paper on ‘Biomarker Driven Population Enrichment for Adaptive Oncology Trials,’ (forthcoming in Statistics in Medicine) which provides an innovative method for using two-stage adaptive...

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Topics: Oncology, Access to Paper PDF, Enrichment, Adaptive Clinical Trials


StatXact 25th Anniversary: A Horizon for the Stars

Posted by Esha Senchaudhuri

Apr 21, 2014 3:57:00 PM

The core methodological problem that would eventually spur the development of Cytel’s StatXact software was first posed by Harvard’s Marvin Zelen at a computational seminar in the late 1970s. Zelen, a distinguished professor of statistical sciences and head of the Department of Biostatistics at Harvard University, was also serving as the Director of the Dana Farber Cancer Institute.

The...

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Topics: StatXact, Nitin Patel, Cyrus Mehta, White Paper, Statistics Article full PDF, Oncology, Access to Paper PDF, Exact Tests, Marvin Zelen, Statistical Puzzles


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