Perspectives on Enquiry & Evidence

The U.S. FDA has recently provided specific guidance[i] on the design and conduct of trials incorporating an external..

Those familiar with simulation-guided design (SGD) know that it can be used for a wealth of clinical trial options:..

Over the past years, probably the entire last decade, there have been several discussions on how to handle multiple..

For clinical development and research and development teams, the Pareto Frontier can perform two functions. Let’s take..

Asthma affects more than 235 million people worldwide, and due to lacking effective implementation of clinical..

Should your clinical trial be adaptive? Trials that include a prospectively planned modification based on an interim..

People think in Bayesian terms all the time: we use prior information and the evidence at hand to make decisions in our..

Ever since the first immune checkpoint inhibitor was approved for market nearly twelve years ago, the industry has..

A small biotech’s conventional carcinoma trial design was too expensive to implement and did not offer the opportunity..