The Cytel Blog: Perspectives on Enquiry & Evidence

The world's leading supplier of statistical insight to decision-makers in the lifesciences brings you debate and discussion of the newest trends in statistics and quantitative strategy.

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September 8, 2021

Progression Free Survival or Overall Survival? Reconciling an old debate with modern technology

A key decision in the design of clinical trials in oncology involves whether to select progression free survival (PFS)..

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August 18, 2021

What does it mean to reduce the risk of a faulty conclusion? A closer look at a new case study.

During the design of a clinical trial, many biotechs want to substantially reduce the risk of a good new therapy being..

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August 10, 2021

CLRPerm: Cytel Scientists and Collaborators Propose a New Method for Meta-analysis for Rare Events

A few weeks ago I wrote about new research conducted by Cytel statisticians, on the challenge of conducting..

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August 9, 2021

When to make decisions? Strategic planning of interim looks.

Recently we discussed examining clinical development through a Bayesian lens, in honor of Cytel co-founder Nitin Patel..

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July 28, 2021

Lessons Learned from Leveraging Computing Power for Clinical Strategy

“We found an optimal design in hours that might have taken months to find using standard methods,” reflected Fabien..

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July 27, 2021

Thinking of Clinical Development from a Bayesian Lens

Program and portfolio optimization creates a framework throughout the course of the clinical development journey, that..

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July 22, 2021

The Risk of Under-exploring Trial Design Options: A New Case Study

Earlier this year, Cytel founder Cyrus Mehta observed that clinical trial design is often treated like an art rather..

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July 14, 2021

Novel Uses of Scoring Functions in Clinical Trial Design Selection

For decades, statisticians have cultivated methods to optimize and de-risk clinical trials for strong regulatory..

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July 12, 2021

Meta-Analysis for Rare Events: Using Confidence Distributions to Manage Statistical Heterogeneity

Medical researchers and public health experts are becoming more reliant on meta-analyses to capture in summary form,..

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The Cytel Blog: Perspectives on Enquiry & Evidence

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