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https://www.cytel.com/blog/how-to-determine-if-your-clinical-trial-has-sufficient-data
June 22, 2022
It can be difficult to estimate just how much time and data you need to address the multitude of considerations that..
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https://www.cytel.com/blog/how-to-use-historical-data-to-mitigate-clinical-trial-risk-through-forecasting-and-statistical-design
March 23, 2022
For over a decade, the number one reason cited for trial discontinuity has been challenges associated with recruitment..
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https://www.cytel.com/blog/a-bayesian-optimal-design-advancing-the-precision-medicine-approach
September 15, 2021
There is recognized heterogeneity within any given tumor‐type from patient to patient (inter‐patient heterogeneity),..
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https://www.cytel.com/blog/use-of-rolling-enrollment-designs-to-accelerate-clinical-trials
July 2, 2021
Popular statistical designs, such as CRM (O’Quigley et al., 1990), mTPI-2 (Guo et al., 2017), and i3+3 (Liu et al.,..
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https://www.cytel.com/blog/use-of-bayesian-approach-in-basket-trial-design
May 28, 2021
Advancements in biomarkers and momentum in precision medicine has paved the foundation for complex studies like basket..
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https://www.cytel.com/blog/single-arm-multi-stage-phase-2-cancer-trials-reviewing-essential-new-designs
March 5, 2021
Early stage Phase 2 clinical trials are often designed as multi-stage single arm trials, which quickly identify..
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https://www.cytel.com/blog/introduction-to-evidence-synthesis-and-bayesian-dynamic-borrowing
February 18, 2021
In the last few years, there has been a growing interest in historical borrowing or augmented trials. There is an..
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https://www.cytel.com/blog/cytel-thought-leadership-on-power-of-bayesian-methods
January 26, 2021
Bayesian models offer a flexible way of incorporating historical controls in the analysis of trial data (whether single..
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https://www.cytel.com/blog/meta-analytic-predictive-priors-generation-and-comparisons
October 5, 2020
Staying abreast of the rapid pace of clinical development means adopting innovative or computationally intensive..
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