June 14, 2023
Medical research has come a long way in recent years, fueled by innovative trial designs that challenge traditional...
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October 3, 2022
The wider availability of electronic health data, medical registries, and even larger proprietary datasets means that...
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March 23, 2022
For over a decade, the number one reason cited for trial discontinuity has been challenges associated with recruitment...
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September 15, 2021
There is recognized heterogeneity within any given tumor‐type from patient to patient (inter‐patient heterogeneity),...
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July 2, 2021
Popular statistical designs, such as CRM (O’Quigley et al., 1990), mTPI-2 (Guo et al., 2017), and i3+3 (Liu et al.,...
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May 28, 2021
Advancements in biomarkers and momentum in precision medicine has paved the foundation for complex studies like basket...
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March 5, 2021
Early stage Phase 2 clinical trials are often designed as multi-stage single arm trials, which quickly identify...
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February 18, 2021
In the last few years, there has been a growing interest in historical borrowing or augmented trials. There is an...
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January 26, 2021
Bayesian models offer a flexible way of incorporating historical controls in the analysis of trial data (whether single...
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May 19, 2014
Pantelis Vlachos, PhD, is a Director at Cytel Consulting. He works with a team of experts who regularly assist clinical...
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