
Perspectives on Enquiry & Evidence
Cytel's blog featuring the latest industry insights.

October 3, 2022
The wider availability of electronic health data, medical registries, and even larger proprietary datasets means that..
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June 22, 2022
How to Determine if Your Clinical Trial Has Sufficient Data?
It can be difficult to estimate just how much time and data you need to address the multitude of considerations that..
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March 23, 2022
How to Use Historical Data to Mitigate Clinical Trial Risk
For over a decade, the number one reason cited for trial discontinuity has been challenges associated with recruitment..
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September 15, 2021
A Bayesian Optimal Design Advancing the Precision Medicine Approach
There is recognized heterogeneity within any given tumor‐type from patient to patient (inter‐patient heterogeneity),..
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July 2, 2021
Use of Rolling-enrollment Designs to Accelerate Clinical Trials
Popular statistical designs, such as CRM (O’Quigley et al., 1990), mTPI-2 (Guo et al., 2017), and i3+3 (Liu et al.,..
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May 28, 2021
Use of Bayesian Approach in Basket Trial Design
Advancements in biomarkers and momentum in precision medicine has paved the foundation for complex studies like basket..
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March 5, 2021
Single Arm Multi-Stage Phase 2 Cancer Trials
Early stage Phase 2 clinical trials are often designed as multi-stage single arm trials, which quickly identify..
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February 18, 2021
Introduction to Evidence Synthesis and Bayesian dynamic borrowing
In the last few years, there has been a growing interest in historical borrowing or augmented trials. There is an..
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January 26, 2021
Cytel Thought Leadership on Power of Bayesian Methods
Bayesian models offer a flexible way of incorporating historical controls in the analysis of trial data (whether single..
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October 5, 2020
The Meta-Analytic-Predictive Priors Generation and Comparisons
Staying abreast of the rapid pace of clinical development means adopting innovative or computationally intensive..
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May 19, 2014
Frequentist? Time for an update!
Pantelis Vlachos, PhD, is a Director at Cytel Consulting. He works with a team of experts who regularly assist clinical..
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