The Rev Bayes Parties with Cytel at JSM 2014

Posted by Esha Senchaudhuri

Aug 8, 2014 9:00:00 AM

Photos leaked from JSM 2014 appear to show the Reverend Bayes partying with his entourage at the Cytel Cocktail Hour, held at Boston’s Seaport Hotel on August 4, 2014. Bayes is, of course, one of the stars of Cytel’s East 6.3, a modular software package driving drug development through high quality trial design and simulations. Bayes's contributions to the East ESCALATE and East PREDICT modules are posited to transform early phase dose-escalation and interim decision-making. The Reverend has also made scene-stealing cameo appearances in a number of projects with Cytel Consulting.

Read More

Topics: East 6.3, Dose-Escalation, Bayesian Methods, Cytel Consulting, East PREDICT, East ESCALATE


Bayesian Approaches in Clinical Trials: Updates on Tools & Techniques

Posted by Esha Senchaudhuri

Jul 31, 2014 4:26:00 AM

Statisticians at Cytel are staunch advocates of the use of Bayesian methods in clinical trials. This summer's Joint Statistical Meeting will feature a panel on "Study Milestone Timeline Projection in Multi-Center Trials: Bayesian and Frequentist Approaches with Real-Life Applications" with three papers co-authored by Cytel experts. The Cytel papers will center on Bayesian  approaches for enrollment prediction, which is essential for proper trial forecasting and interim decision-making.

Read More

Topics: Dose-Escalation, Bayesian Methods


Cytel Animation: Modern Dose Escalation Phase 1 Trials

Posted by Charles Liu

Jul 15, 2014 8:00:00 AM

 

Learn More about East® ESCALATE

Do you design or analyze Phase 1 dose escalation trials? Have you considered methods other than 3+3? This new Cytel video demonstrates how East ESCALATE can help you to explore your options. 

Read More

Topics: Dose-Escalation, Bayesian Methods, Cytel Videos


Frequentist? Time for an update!

Posted by Dr. Pantelis Vlachos, Director at Cytel Consulting

May 19, 2014 10:22:00 PM

Pantelis Vlachos, PhD, is a Director at Cytel Consulting. He works with a team of experts who regularly assist clinical study teams with the design and implementation of Bayesian methods. In this blog post, Pantelis describes key benefits of Bayesian analyses for clinical trials.

Read More

Topics: Bayesian Methods, Cytel Consulting, Trial Monitoring


5 Reasons to Invest in Bayesian Dose-Escalation Methods

Posted by Esha Senchaudhuri

May 8, 2014 7:54:00 AM

( Editor's note: This post has been refreshed in December 2016)

Model based algorithms for Phase I dose-escalation have been in existence for nearly thirty years. Despite guarantees of increased statistical power and greater accuracy, there remains a clear preference for rule based algorithms amongst clinicians. The explanation for this is as old as the models themselves.

Read More

Topics: Oncology, Dose-Escalation, Bayesian Methods, East ESCALATE, EAST 6.4


The Cytel blog keeps you up to speed with the latest developments in biostatistics and clinical biometrics.  Sign up for updates direct to your inbox. You can unsubscribe at any time.

 

Posts by Topic

see all

Recent Posts