Michael Proschan on 'Blinded Adaptations, Permutations and t-tests' (Link to Slides)

Posted by Cytel

Oct 30, 2014 10:28:00 AM

 During last week’s East Users Group Meeting, Michael Proschan of the NIH and NIAID, gave a presentation on ‘Blinded Adaptations, Permutations and t-tests.’ Given the close connection between adaptive t-tests and adaptive permutation tests, Proschan argued that it is possible to determine the validity of an adaptive t-test from the validity of an adaptive permutation test. Proschan concludes that in adaptive settings, “permutation tests are often valid in adaptive settings, even if blind is maintained.”

Michael's slides are available below. You can also find two of his recent papers on blinded adaptations in the 'Related Items of Interest' section.  

View Slides

 


Related Items of Interest

Posch, Martin, and Michael A. Proschan. "Unplanned adaptations before breaking the blind." Statistics in medicine 31.30 (2012): 4146-4153.

Proschan, Michael, Ekkehard Glimm, and Martin Posch. "Connections between permutation and t‐tests: relevance to adaptive methods." Statistics in medicine (2014).

Topics: permutations, Blind and Unblind Trials, t-tests, Adaptive Clinical Trials

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