New Publication: Design and Monitoring of Multi-Arm Multi-Stage Clinical Trials

Posted by Cytel

Mar 29, 2017 8:29:00 AM

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With an increasing interest in platform designs and other innovative designs that involve multiple comparisons over multiple stages, the importance of Multi-Arm Multi-Stage ( MAMS) designs is set to rise.

The multi-arm approach evaluates a number of experimental arms against a common control within a single trial.  This is combined with a ‘multi-stage’ adaptive approach which can increase efficiency by reviewing outcomes at key activity stages through interim analyses. One key historic limitation to implementing these designs has been the inherent computational challenge involved- with complexity growing  with the number of arms as well as with number of stages. 

An important new paper Design and Monitoring of Multi-Arm Multi-Stage Clinical Trials  in the journal  Biometrics, by Pranab Ghosh, Lingyun LiuPralay Senchaudhuri, Ping Gao and Cyrus Mehta  shares ground-breaking algorithms to help compute MAMS boundaries efficiently , and so make the use of these designs practical for researchers. 

 The article is available to read in full via the button below.

 

Article

References

Ghosh, P., Liu, L., Senchaudhuri, P., Gao, P. and Mehta, C. (2017), Design and monitoring of multi-arm multi-stage clinical trials. Biom. doi:10.1111/biom.12687

 

 

 

 

Topics: Adaptive Clinical Trials, Multi-Arm Studies, Multi-Arm Multi-Stage Studies, biostatistics, adaptive designs

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