Using ToxTools® for Dose Response Analysis

Example 1: Binary Endpoint Example
Percentage of lung tumors in female mice were fit to dose using a probit model.

Example 2: Continuous Endpoint Example
A developmental toxicity dataset, concentrating on maternal weight measurements.

Example 3: Clustered Binary Example
A developmental toxicity dataset, concentrating on fetal outcomes. Note that the fetal death outcomes are clustered due to the "litter effect."

Example 4: Joint Continuous and Binary Outcomes
This example involves multivariate modeling of clustered weights and malformation from developmental toxicity data.

Example 5: Developmental Toxicology
A developmental toxicology study looked at 1142 individual live fetuses born to 102 pregnant mice exposed to 0, 0.25, 0.5 or 1.0 unit of a chemical.

Example 6: Test of Trend
A study, conducted in mice, tested a potentially harmful drug at the following doses: 0, 1, 10, 100 mg/kg.