Vesnarinone Trial Among Patients with Heart Failure

A total of 189 centers in the United States and Canada accrued 3833 patients with heart failure to the Vesnarinone trial over a 15-month period between 1995 and 1996. (New England Journal of Medicine, 1998).

Weight Control Trial of Orlisat in Obese Subjects

18 U.S. research centers participated in a clinical trial where obese adults were randomized to receive either Orlisat or placebo plus dietary intervention (JAMA, 1999).

Propanolol Beta-Blocker Trial

In the late 1970's, the National Heart, Lung and Blood Institute sponsored a double-blind, randomized multi-center trial to test the drug propanolol, a beta-blocker, against a placebo among patients who had previously experienced acute myocardial infarction.

A Case Study: Design and Interim Monitoring of a Randomized Clinical Trial Using East

Protocol 8433 (conducted in the United States by the Cancer and Leukemia Oncology Group B--CALGB) was a phase III clinical trial of standard radiotherapy with or without a neoadjuvant combination chemotherapy in patients with regional stage III non-small-cell lung cancer.