What does East® do?

Successful clinical studies begin with the right trial design. East® 5 guides trial planners through the myriad of design options while offering more adaptive, group sequential and fixed-sample size clinical trial designs than any other commercial software package.

What sets East® apart?

With an ever increasing array of statistical methods, simulation and comparison tools, East® is the most widely used clinical trial design software system in use today. Optional modules - East® Adapt, East® Surv, East® SurvAdapt, East® Xact - further expand East’s capabilities.

Are the trial designs validated?
What is the regulatory perspective on East®?

All methodologies in East are fully referenced and all designs are highly validated. Hundreds of adaptive and conventional East-designed trials have been accepted and successfully implemented by biopharmaceuticals, device companies and research institutions worldwide.

East® is currently in use at FDA divisions CDER, CBER and CDRH. Cytel experts periodically train FDA statisticians in East® use, along with advances in the statistics of adaptive, dose-finding, and group sequential designs. East® is also referred to at the EMA, MHRA and other European clinical trial regulatory overseers.

What’s new in East® 5

New additions to the industry's foremost trial design system include:

• Expanded visualization tools for better understanding of trial design concepts among trial planners, clinical operations and regulators
• New report-ready tables for protocol review and study-results submission
• Better designs for trials using smaller sample sizes
• More single-look trial designs and simulations
• More stopping boundary specifications options, including Lan-DeMets, Haybittle-Peto, Wang, Tsiatis and other published or user-specified error-spending functions

See all trial design and simulations methods in the East® brochure

From Cyrus Mehta, Cytel President, Co-Founder

“East 5 builds on Cytel’s reputation for versatility and accuracy. Many new features came from ideas provided by users, for example better ways to share trial concepts amongst non-statisticians like ‘Split Screen’ and displaying of multiple graphics to compare results. Helping our customers confidently determine the best design and clearly communicating the trial's concepts is what East 5 is all about.”

Options for East®

East® Adapt

Should the trial design be adaptive or group sequential? How many patients, how much time and what resources could be saved with an adaptive design? Which adaptive options - sample size, spending function, number and spacing of interim looks - are best?