CrossOver™ is the entirely new member of the Cytel Studio® family developed by Cytel statisticians to more accurately analyze data using 2x2 crossover experiments.

The initial version of CrossOver is bundled free with any purchase or renewed maintenance of new StatXact® or LogXact®.

What can you accomplish with CrossOver?

While applicable to a wide variety of practice areas, 2x2 crossover trials are especially valuable in clinical research studies.

See CrossOver example using actual study data

Cytel's CrossOver™ offers a choice of parametric and nonparametric operations for both continuous and binary data. Consider the tests and procedures included in this new module:

Tests for Continuous Data

Carryover Effect

• Exact Test Using Ranks (Wilcoxon MW, Van Der Waerden, Savage tests)
• Exact Test Using Original Data

Period Effect

• Exact Test Using Ranks (Wilcoxon MW, Van Der Waerden, Savage tests)
• Exact Test Using Original Data
• Exact Estimate of Difference (Hodges-Lehmann Estimate)

Treatment Effect

• Exact Test Using Ranks (Wilcoxon MW, Van Der Waerden, Savage tests)
• Exact Test Using Original Data
• Estimate Difference (Hodges-Lehman Estimate)

Tests for Binary Data Period Effect

• Exact Mainland-Gart Test
• Exact Prescott's Test

Treatment Effect

• Exact Mainland-Gart Test
• Exact Prescott's Test

Power and Sample Size

For superiority tests using difference of means of two treatments

Descriptive and Summary PK/PD Parameter Statistics and Plots

New procedures enable the following computations for time vs. concentration data types in 2x2 crossover trials:

AUC: Area Under the Curve. Tmax: Time of Maximum Concentration. Cmax: Maximum Concentration. T1/2 : Half Life Summary Statistics for Group vs. Period Subject Profile Plots Treatment vs. Period Plot

We're ready to answer your questions and determine the best licensing arrangement for you and your organization.

Call us at +617.661.2011 M-F, 9AM - 5 PM EST or email sales@cytel.com