Planners of dose ranging studies are challenged to create trials that determine the best dose level(s) to carry into confirmatory development.

Compass® is the first adaptive trial composition package to combine frequentist and Bayesian adaptive methods, R code integration, together with powerful simulation and visualization capabilities.
Compass® allows users to:

• choose from frequentist or Bayesian adaptive methods suitable for dose-finding studies
• run and write R scripts relevant:
• generate trial simulations and visualizations of a design's operating characteristics
• easily share trial concepts amongst planning and execution teams
• automatically amass libraries for fast recall in future projects

What can I do with Compass®?

• construct a single trial trial that combines PoC and dose-ranging objectives
• easily compare multiple adaptive design scenarios to assess best method/design premise
• improve understanding of trial dynamics for better decision-making
• be certain to carry the right dose into the registration development stage
• adaptively allocate subjects to doses during the trial (in conjunction with Cytel randomization technology)

How is this accomplished?

Compass® provides an advanced statistical simulation environment to design, assess options and allocate subjects in adaptive dose-finding studies. Click here to compare the adaptive methods popular in dose-finding trials .

Frequentist design methods

• Anova
• Up and Down
• t-test based Up and Down
• Maximizing

Bayesian design methods

• Normal Dynamic Linear Model (NDLM)
• Four Parameter Logistic (4PL)
• Emax

How can I be certain of the results?

Cytel has been at the forefront of applying adaptive trials in clinical practice for several years. Compass® was developed from this experience, plus knowledge gained from East®, the extensively used adaptive and group sequential software for registration studies.

47 of the top 50 biopharmaceutical companies use Cytel software to design, simulate and analyze their trials. The statistical methods and simulation implementation in Compass® have been validated in practice and the resultant designs accepted by the FDA and EMA.

How can I assess Compass®?

Best way: click your contact link at top right to schedule a peronsal Compass® demonstration, and/or order a free 30-day trial.
Or at your convenience watch a replay of the 45 minute demonstration webinarby Cytel's Director of Biostatistics, Yannis Jemiai.

How is Compass® priced?

Compass is sold on annual license-basis. Discounts for academic/non-profit use, and multiple licensing are available.

If from a company email Andrea Caiello McSweeney

If from academic or nonprofit organization email with this link