EastXact®

EastXact™ is a new suite of design options for Cytel’s East® and specifically applicable to clinical trials with binomial endpoints with small sample sizes, or proportions that are close to zero.

What does EastXact® do?
The new EastXact® is an optional “module” that extends the capabilities of Cytel’s East clinical trial design software system.  EastXact® provides clinical trial planners with statistical design and simulation tools utilizing exact binomial distributions.

Why is it important?
In small sample sizes or with very high/low proportions, asymptotic normal approximations may lead to inaccurate power calculations. EastXact utilizes statistical methods based on exact binomial distributions, which are more precise than asymptotic normal approximations especially in calculating the power of a trial.

For whom is it designed?
Any statistician designing a clinical trial with a binomial endpoint, particularly in studies with small sample sizes or very high/low event rates.

What therapeutic areas benefit?
Most if not all therapeutic areas are applicable, but especially in trials for oncology, infectious diseases and vaccines.

Please contact us for more information on EastXacts's specific capabilities, along with license and training options.